Structure and Dynamics of Membrane Proteins by Magic Angle Spinning Solid-State NMR

Membrane proteins remain difficult to study by traditional methods. Magic angle spinning solid-state NMR (MAS SSNMR) methods present an important lit approach for studying membrane proteins of moderate size. Emerging MAS SSNMR methods are based out extensive assignments of the nuclei as a basis for structure determination and characterization of function. These methods live already been used to characterize fibrils and globular proteins and are being increasingly used to study membrane proteins embedded in lipids. This review highlights recent applications to intrinsic membrane proteins and Summarizes recent technical advances that will enable these methods to be utilized for more complex membrane protein systems in the near future.