Synthesis of 1,2,4-triazolo[5′,1′:2,3][1,3]thiazino[6,5-b]indol-10(5H)-ones based on 2-chloro-1H-indole-3-carbaldehyde

被引：3

作者：

Vikrishchuk, Natalia, I ^{[1
]}

Tkachev, Valerii V. ^{[2
,3
]}

Borodkin, Gennady S. ^{[4
]}

Gazieva, Galina A. ^{[5
]}

Shilov, Gennady, V ^{[2
]}

机构：

[1] Southern Fed Univ, Chem Dept, 7 Zorge St, Rostov Na Donu 344090, Russia

[2] Russian Acad Sci, Inst Problems Chem Phys, Chernogolovka 142432, Russia

[3] Russian Acad Sci, Inst Physiologically Act Subst, Chernogolovka 142432, Russia

[4] Southern Fed Univ, Inst Phys & Organ Chem, 194-2 Stachka Ave, Rostov Na Donu 344090, Russia

[5] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Prosp, Moscow 119991, Russia

来源：

TETRAHEDRON LETTERS | 2020年 / 61卷 / 45期

关键词：

Indole; N-N bond cleavage; Rearrangement; Triazolothiazino[6,5-b]indol-10(5H)-one; ANTIVIRAL ACTIVITY;

D O I：

10.1016/j.tetlet.2020.152490

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

As a result of the reaction of 2-chloro-1H-indole-3-carbaldehydes with 4-amino-5-alkyl-4H-1,2,4-triazole-3-thiols in DMF, representatives of a new heterocyclic system, 1,2,4-triazolo[5',1':2,3][1,3]thiazino [6,5-b]indol-10(5H)-one, were obtained. The reaction proceeds unusually, with a the release of an ammonia molecule. The structure of 1,2,4-triazolo[5',1':2,3][1,3]thiazino[6,5-b]indol-10(5H)-ones was established by X-ray diffraction. The obtained compounds contain rutalexin scaffold in the structure and are promising in terms of biological activity. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：3

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