The concepts of Guillain - Barre syndrome have changed substantially over the last 10 years, and the last 2 years have been no exception, Guillain - Barre syndrome is now recognized as a heterogeneous disorder with many clinical manifestations. Most current investigations are centered on the hypothesis of molecular mimicry. The major challenge now is to identify the precise mechanisms of nerve fiber injury and to determine how to prevent immune injury. curr Opin Neurol 12:389-394. (C) 1999 Lippincott Williams & Wilkins.
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Univ Malaya, Fac Med, Dept Med, Neurol Unit, Kuala Lumpur 50603, MalaysiaUniv Malaya, Fac Med, Dept Med, Neurol Unit, Kuala Lumpur 50603, Malaysia
Shahrizaila, Nortina
Lehmann, Helmar C.
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Univ Cologne, Fac Med, Dept Neurol, Cologne, Germany
Univ Cologne, Univ Hosp Cologne, Cologne, GermanyUniv Malaya, Fac Med, Dept Med, Neurol Unit, Kuala Lumpur 50603, Malaysia
Lehmann, Helmar C.
Kuwabara, Satoshi
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Chiba Univ, Grad Sch Med, Dept Neurol, Chiba, JapanUniv Malaya, Fac Med, Dept Med, Neurol Unit, Kuala Lumpur 50603, Malaysia