Impact of taxanes on androgen receptor signaling

被引：16

作者：

Bai, Shanshan ^{[1
,2
]}

Zhang, Bryan Y. ^{[3
]}

Dong, Yan ^{[2
]}

机构：

[1] Jilin Univ, Coll Life Sci, Changchun 130012, Jilin, Peoples R China

[2] Tulane Univ, Sch Med, Tulane Canc Ctr, Dept Struct & Cellular Biol, New Orleans, LA 70112 USA

[3] Lusher Charter Sch, New Orleans, LA 70115 USA

来源：

ASIAN JOURNAL OF ANDROLOGY | 2019年 / 21卷 / 03期

基金：

美国国家卫生研究院; 中国国家自然科学基金;

关键词：

androgen receptor; androgen receptor splice variant; cabazitaxel; docetaxel; prostate cancer; taxane; RESISTANT PROSTATE-CANCER; SPLICE VARIANTS; ANTITUMOR-ACTIVITY; CROSS-RESISTANCE; DOCETAXEL; CABAZITAXEL; ABIRATERONE; ENZALUTAMIDE; MITOXANTRONE; PHARMACOKINETICS;

D O I：

10.4103/aja.aja_37_18

中图分类号：

R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

摘要：

The development and progression of metastatic castration-resistant prostate cancer is the major challenge in the treatment of advanced prostate cancer. The androgen receptor signaling pathway remains active in metastatic castration-resistant prostate cancer. Docetaxel and cabazitaxel are the first- and second-line chemotherapy, respectively, for patients with metastatic castration-resistant prostate cancer. These two taxanes, in general, function by (i) inhibiting mitosis and inducing apoptosis and (ii) preventing microtubule-dependent cargo trafficking. In prostate cancer, taxanes have been reported to inhibit the nuclear translocation and activity of the androgen receptor. However, whether this is attainable or not clinically remains controversial. In this review, we will provide a comprehensive view of the effects of taxanes on androgen receptor signaling in prostate cancer.

引用

页码：249 / 252

页数：4

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