5-HT7 Receptor Antagonists with an Unprecedented Selectivity Profile

被引：3

作者：

Ates, Ali ^{[1
]}

Burssens, Pierre ^{[1
]}

Lorthioir, Olivier ^{[1
]}

Lo Brutto, Patrick ^{[1
]}

Dehon, Gwenael ^{[1
]}

Keyaerts, Jean ^{[1
]}

Coloretti, Francis ^{[1
]}

Lallemand, Benedicte ^{[1
]}

Verbois, Valerie ^{[1
]}

Gillard, Michel ^{[1
]}

Vermeiren, Celine ^{[1
]}

机构：

[1] UCB Pharma, UCB NewMed, Chemin Foriest, B-1420 Braine Lalleud, Belgium

来源：

CHEMMEDCHEM | 2018年 / 13卷 / 08期

关键词：

5-HT7; receptor; antagonists; selectivity; serotonin; SEROTONIN RECEPTOR; MOLECULAR-CLONING; ADENYLATE-CYCLASE; LIGANDS;

D O I：

10.1002/cmdc.201800026

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

[No abstract available]

引用

页码：795 / 802

页数：8

共 16 条

[1]

BARD JA, 1993, J BIOL CHEM, V268, P23422

[2] Translational Evaluation of JNJ-18038683, a 5-Hydroxytryptamine Type 7 Receptor Antagonist, on Rapid Eye Movement Sleep and in Major Depressive Disorder [J].

Bonaventure, Pascal ;

Dugovic, Christine ;

Kramer, Michelle ;

De Boer, Peter ;

Singh, Jaskaran ;

Wilson, Sue ;

Bertelsen, Kirk ;

Di, Jianing ;

Shelton, Jonathan ;

Aluisio, Leah ;

Dvorak, Lisa ;

Fraser, Ian ;

Lord, Brian ;

Nepomuceno, Diane ;

Ahnaou, Abdellah ;

Drinkenburg, Wilhelmus ;

Chai, Wenying ;

Dvorak, Curt ;

Sands, Steve ;

Carruthers, Nicholas ;

Lovenberg, Timothy W. .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2012, 342 (02) :429-440

[3]

CHENG Y, 1973, BIOCHEM PHARMACOL, V22, P3099

[4]

Degorce Francois, 2009, Curr Chem Genomics, V3, P22, DOI 10.2174/1875397300903010022

[5] Serotonergic 5-HT7 receptors and cognition [J].

Gasbarri, Antonella ;

Pompili, Assunta .

REVIEWS IN THE NEUROSCIENCES, 2014, 25 (03) :311-323

[6] The 5-HT7 receptor and disorders of the nervous system: an overview [J].

Hedlund, Peter B. .

PSYCHOPHARMACOLOGY, 2009, 206 (03) :345-354

[7] Serotonin7 receptors (5-HT7Rs) and their ligands [J].

Leopoldo, A .

CURRENT MEDICINAL CHEMISTRY, 2004, 11 (05) :629-661

[8] Serotonin 5-HT7 receptor agents: Structure-activity relationships and potential therapeutic applications in central nervous system disorders [J].

Leopoldo, Marcello ;

Lacivita, Enza ;

Berardi, Francesco ;

Perrone, Roberto ;

Hedlund, Peter B. .

PHARMACOLOGY & THERAPEUTICS, 2011, 129 (02) :120-148

[9] A novel, potent, and selective 5-HT7 antagonist:: (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970) [J].

Lovell, PJ ;

Bromidge, SM ;

Dabbs, S ;

Duckworth, DM ;

Forbes, IT ;

Jennings, AJ ;

King, FD ;

Middlemiss, DN ;

Rahman, SK ;

Saunders, DV ;

Collin, LL ;

Hagan, JJ ;

Riley, GJ ;

Thomas, DR .

JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (03) :342-345

[10] A NOVEL ADENYLYL CYCLASE-ACTIVATING SEROTONIN RECEPTOR (5-HT7) IMPLICATED IN THE REGULATION OF MAMMALIAN CIRCADIAN-RHYTHMS [J].

LOVENBERG, TW ;

BARON, BM ;

DELECEA, L ;

MILLER, JD ;

PROSSER, RA ;

REA, MA ;

FOYE, PE ;

RACKE, M ;

SLONE, AL ;

SIEGEL, BW ;

DANIELSON, PE ;

SUTCLIFFE, JG ;

ERLANDER, MG .

NEURON, 1993, 11 (03) :449-458

← 1 2 →