Asperuloside Improves Obesity and Type 2 Diabetes through Modulation of Gut Microbiota and Metabolic Signaling

被引：27

作者：

Nakamura, Anna ^{[1
,2
]}

Yokoyama, Yoko ^{[1
,2
]}

Tanaka, Kazuki ^{[1
,3
,4
]}

Benegiamo, Giorgia ^{[5
]}

Hirayama, Akiyoshi ^{[3
]}

Zhu, Qi ^{[2
,6
]}

Kitamura, Naho ^{[1
,2
]}

Sugizaki, Taichi ^{[7
]}

Morimoto, Kohkichi ^{[7
]}

Itoh, Hiroshi ^{[7
]}

Fukuda, Shinji ^{[3
,4
,8
]}

Auwerx, Johan ^{[5
]}

Tsubota, Kazuo ^{[2
,9
]}

Watanabe, Mitsuhiro ^{[1
,2
,6
,7
,9
]}

机构：

[1] Keio Univ, Grad Sch Media & Governance, Syst Biol Program, Fujisawa, Kanagawa 2520882, Japan

[2] Keio Res Inst SFC, Hlth Sci Lab, Fujisawa, Kanagawa 2520882, Japan

[3] Keio Univ, Inst Adv Biosci, Tsuruoka, Yamagata 9970052, Japan

[4] Kanagawa Inst Ind Sci & Technol, Intestinal Microbiota Project, Kawasaki, Kanagawa 2100821, Japan

[5] Ecole Polytech Fed Lausanne EPFL, Lab Integrat & Syst Physiol, CH-1015 Lausanne, Switzerland

[6] Keio Univ, Dept Environm & Informat Studies, Fujisawa, Kanagawa 2520882, Japan

[7] Keio Univ, Dept Internal Med, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan

[8] Univ Tsukuba, Transborder Med Res Ctr, Tsukuba, Ibaraki 3058575, Japan

[9] Keio Univ, Dept Ophthalmol, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan

来源：

ISCIENCE | 2020年 / 23卷 / 09期

基金：

欧洲研究理事会; 瑞士国家科学基金会;

关键词：

GLUCAGON-LIKE PEPTIDE-1; DIET-INDUCED OBESITY; INFLAMMATION; MECHANISMS; MICE; POPULATION; RESISTANCE; SUCCINATE; PROTECTS; EXTRACT;

D O I：

10.1016/j.isci.2020.101522

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Asperuloside (ASP) is an iridoid glycoside that is extracted from Eucommia leaves. Eucommia is used in traditional Chinese medicine and has a long history of benefits on health and longevity. Here, we investigated the impact of ASP on obesity-related metabolic disorders and show that ASP reduces body weight gain, glucose intolerance, and insulin resistance effectively in mice fed with a high-fat diet (HFD). Intestinal dysbiosis is closely linked with metabolic disorders. Our data indicate that ASP achieves these benefits on metabolic homeostasis by reversing HFD-induced gut dysbiosis and by changing gut-derived secondary metabolites and metabolic signaling. Our results indicate that ASP may be used to regulate gut microbiota for the treatment of obesity and type 2 diabetes.

引用

页数：20

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