Fabrication of platinum nitrogen-doped graphene nanocomposite modified electrode for the electrochemical detection of acetaminophen

被引:122
作者
Anuar, Nadzirah Sofia [1 ]
Basirun, Wan Jeffrey [1 ,2 ]
Ladan, Magaji [1 ,3 ]
Shalauddin, Md. [1 ,2 ]
Mehmood, Muhammad Shahid [4 ]
机构
[1] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur 50603, Malaysia
[2] Univ Malaya, Inst Nanotechnol & Catalysis NanoCat, Kuala Lumpur 50603, Malaysia
[3] Bayero Univ Kano, Dept Pure & Ind Chem, Kano, Nigeria
[4] Univ Malaya, Fac Sci, Dept Phys, Kuala Lumpur 50603, Malaysia
关键词
Acetaminophen; Electrochemical sensor; Graphene; Platinum nanoparticles; GLASSY-CARBON ELECTRODE; SIMULTANEOUS VOLTAMMETRIC DETERMINATION; PASTE ELECTRODE; ASCORBIC-ACID; SILVER NANOPARTICLES; METHANOL OXIDATION; HYDROGEN-PEROXIDE; OXYGEN REDUCTION; SOLAR-CELLS; PARACETAMOL;
D O I
10.1016/j.snb.2018.03.138
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
An electrochemical sensor for the determination of acetaminophen (AC) was fabricated on glassy carbon electrode (GCE) modified with platinum nitrogen-doped graphene (Pt/NGr) nanocomposite. Electro-chemical impedance spectroscopy (EIS), cyclic voltammetry (CV) and square-wave voltammetry (SWV) were performed to investigate the electrochemical behaviour of AC. From the electrochemical results, the synergy between platinum nanoparticles and nitrogen-doped graphene improved the interfacial electron transfer process, thus exhibited a higher catalytic performance towards the electrochemical oxidation of AC. A linear range between 0.05-90 mu mol L-1 for the determination of AC was achieved with a limit of detection of 0.008 mu mol L-1. The prepared sensor demonstrated acceptable reproducibility, stability and good selectivity in the presence of interferences such as ascorbic acid, p-aminophenol and dopamine. In addition, this method showed satisfactory results in commercial tablets. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码:375 / 383
页数:9
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