ESRRG promoter hypermethylation as a diagnostic and prognostic biomarker in laryngeal squamous cell carcinoma

被引：13

作者：

Shen, Zhisen ^{[1
]}

Hu, Yan ^{[2
]}

Zhou, Chongchang ^{[1
]}

Yuan, Jie ^{[2
]}

Xu, Jie ^{[2
]}

Hao, Wenjuan ^{[1
]}

Deng, Hongxia ^{[1
]}

Ye, Dong ^{[1
]}

机构：

[1] Ningbo Univ, Lihuili Hosp, Dept Otorhinolaryngol Head & Neck Surg, Ningbo, Zhejiang, Peoples R China

[2] Ningbo Univ, Med Sch, Dept Otolaryngol, Ningbo, Zhejiang, Peoples R China

来源：

JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2019年 / 33卷 / 06期

关键词：

diagnostics; DNA methylation; estrogen-related receptor gamma; laryngeal squamous cell carcinoma; prognostics; ERR-GAMMA; CANCER; EXPRESSION; METHYLATION; PROLIFERATION; INHIBITION;

D O I：

10.1002/jcla.22899

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background Estrogen-related receptor gamma (ESRRG) has been identified as a tumor suppressor gene in several cancers. We aimed to evaluate ESRRG promoter methylation in laryngeal squamous cell carcinoma (LSCC) and its relative clinical value in LSCC. Methods Bisulfite pyrosequencing assays were performed on 91 pairs of tumor and paracancer tissues from LSCC patients in China. The diagnostic value and overall survival (OS) were analyzed descriptively by receiver operating characteristic (ROC) curves and the Kaplan-Meier methods, respectively. Results The ESRRG promoter was more frequently hypermethylated in tumor tissues than in adjacent tissues (P < 0.01). ESRRG promoter methylation was significantly increased in advanced T stage tumors (P < 0.01) and advanced clinical stage patients (P < 0.01). Moreover, the area under the ROC curve (AUC) value (0.81) indicated high discrimination accuracy. Furthermore, ESRRG hypermethylation was associated with poor OS, as confirmed by Kaplan-Meier survival curves (P < 0.01). Conclusion Our study indicated that ESRRG promoter hypermethylation contributed to LSCC-related risks, primarily tumor progression and survival prognosis, in patients. ESRRG promoter methylation could, therefore, be a diagnostic and prognostic biomarker in LSCC.

引用

页数：7

共 32 条

[1] Prognostic factors analysis of 17,600 melanoma patients: Validation of the American Joint Committee on Cancer melanoma staging system [J].

Balch, CM ;

Soong, SJ ;

Gershenwald, JE ;

Thompson, JF ;

Reintgen, DS ;

Cascinelli, N ;

Urist, M ;

McMasters, KM ;

Ross, MI ;

Kirkwood, JM ;

Atkins, MB ;

Thompson, JA ;

Coit, DG ;

Byrd, D ;

Desmond, R ;

Zhang, YT ;

Liu, PY ;

Lyman, GH ;

Morabito, A .

JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (16) :3622-3634

[2]

Bednarek K, 2018, AM J CANCER RES, V8, P1249

[3] Personalized medicine in metastatic non-small-cell lung cancer: promising targets and current clinical trials [J].

Black, A. ;

Morris, D. .

CURRENT ONCOLOGY, 2012, 19 :S73-S85

[4] Recurrent transcriptional loss of the PCDH17 tumor suppressor in laryngeal squamous cell carcinoma is partially mediated by aberrant promoter DNA methylation [J].

Byzia, Ewa ;

Soloch, Natalia ;

Bodnar, Magdalena ;

Szaumkessel, Marcin ;

Kiwerska, Katarzyna ;

Kostrzewska-Poczekaj, Magdalena ;

Jarmuz-Szymczak, Malgorzata ;

Szylberg, Lukasz ;

Wierzbicka, Malgorzata ;

Bartochowska, Anna ;

Kalinowicz, Ewelina ;

Grenman, Reidar ;

Szyfter, Krzysztof ;

Marszalek, Andrzej ;

Giefing, Maciej .

MOLECULAR CARCINOGENESIS, 2018, 57 (07) :878-885

[5] Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma [J].

Chen, Linyan ;

Zeng, Hao ;

Yang, Jiapeng ;

Lu, Yuqing ;

Zhang, Dan ;

Wang, Jinggan ;

Kuang, Chienyun ;

Zhu, Sha ;

Wang, Manni ;

Ma, Xuelei .

BMC CANCER, 2018, 18

[6] Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions [J].

Dankova, Zuzana ;

Brany, Dusan ;

Dvorska, Dana ;

Nachajova, Marcela ;

Fiolka, Roman ;

Grendar, Marian ;

Hatok, Jozef ;

Kubatka, Peter ;

Holubekova, Veronika ;

Halasova, Erika ;

Bielik, Tibor ;

Zubor, Pavol .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2018, 42 (06) :3318-3328

[7] Diagnostic Value of the Methylation of Multiple Gene Promoters in Serum in Hepatitis B Virus-Related Hepatocellular Carcinoma [J].

Dong, Xueyan ;

Hou, Qiang ;

Chen, Yueming ;

Wang, Xianjun .

DISEASE MARKERS, 2017, 2017

[8] miR-378☆ Mediates Metabolic Shift in Breast Cancer Cells via the PGC-1β/ERRγ Transcriptional Pathway [J].

Eichner, Lillian J. ;

Perry, Marie-Claude ;

Dufour, Catherine R. ;

Bertos, Nicholas ;

Park, Morag ;

St-Pierre, Julie ;

Giguere, Vincent .

CELL METABOLISM, 2010, 12 (04) :352-361

[9] Low mRNA expression levels of kallikrein-related peptidase 4 (KLK4) predict short-term relapse in patients with laryngeal squamous cell carcinoma [J].

Foteinou, Emmanouela ;

Kontos, Christos K. ;

Giotakis, Aris I. ;

Scorilas, Andreas .

BIOLOGICAL CHEMISTRY, 2014, 395 (09) :1051-1062

[10] Differential expression of estrogen-related receptors β and γ (ERRβ and ERRγ) and their clinical significance in human prostate cancer [J].

Fujimura, Tetsuya ;

Takahashi, Satoru ;

Urano, Tomohiko ;

Ijichi, Nobuhiro ;

Ikeda, Kazuhiro ;

Kumagai, Jinpei ;

Murata, Taro ;

Takayama, Kenichi ;

Horie-Inoue, Kuniko ;

Ouchi, Yasuyoshi ;

Muramatsu, Masami ;

Homma, Yukio ;

Inoue, Satoshi .

CANCER SCIENCE, 2010, 101 (03) :646-651

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