Growth variations with opposite clinical outcomes and the emerging role of IGF-1

被引：14

作者：

Papadimitriou, Anastasios ^{[1
]}

Marakaki, Chrisanthi ^{[1
]}

Papadimitriou, Dimitrios T. ^{[2
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Attikon Univ Hosp, Dept Pediat 3, Pediat Endocrinol Unit, Athens, Greece

[2] Aretae Univ Hosp, Marousi & Endocrine Unit, Athens Med Ctr, Pediat Adolescent Endocrinol & Diabet, Athens, Greece

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2022年 / 33卷 / 05期

关键词：

FOR-GESTATIONAL-AGE; CATCH-UP GROWTH; FACTOR-I RECEPTOR; EARLY PUBERTY; NEUROKININ B; CONSTITUTIONAL ADVANCEMENT; GNRH SECRETION; INSULIN; CHILDREN; GIRLS;

D O I：

10.1016/j.tem.2022.02.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Normal growth pattern variations [i.e., constitutional advancement and constitu-tional delay of growth and puberty (CAGP and CDGP)] are the mirror image of each other and are associated with early puberty (EP) and delayed puberty (DP), respectively. Differences between CAGP and CDGP relate not only to auxological characteristics (height, weight) but also to insulin-like growth factor-1 (IGF-1). IGF-1 levels in CAGP are above average whereas in CDGP they are below average, suggesting a role for IGF-1 in the induction of these growth patterns. Herein, we provide data suggesting that early activation of the growth hormone (GH)/IGF-1 axis induces the growth pattern of CAGP. Moreover, we suggest that IGF-1 is a decisive factor for the release of the gonadotropin-releasing hormone (GnRH) inhibition brake that occurs in prepuberty. It is there-fore crucial for puberty onset.

引用

页码：359 / 370

页数：12

共 93 条

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