Regimen-Related Mucosal Injury of the Gut Increased the Incidence of CMV Disease after Allogeneic Bone Marrow Transplantation

Cytomegalovirus (CMV) infection is I of the major causes of morbidity in patients undergoing allogeneic stem cell transplantation (allo-SCT). The incidences of CMV antigenemia and CMV disease in 43 patients who received allogeneic bone marrow trans plantation (BMT) using a reduced-intensity conditioning (RIC) regimen, which mainly consisted of fluclarabine (Flu), busulfan (Bu), and total body irradiation (TBI), were compared with those in 68 patients who received a myeloablative conditioning (MAC) regimen, and risk factors for CMV antigenemia and CMV disease were identified. Before engraftment, grade 3-4 mucosal injury because of the conditioning regimen was significantly decreased in RIC patients (stomatitis: P=.02; diarrhea: P<.01). Rate of engraftment, incidences of acute graft-versus-host disease (aGVHD), and rate of corticosteroid administration were not different in RIC patients and MAC patients. Although the incidences of CMV antigenemia were not significantly different in RIC patients and MAC patients (64.1% versus 57.8%, log rank, P=.59), the incidence of CMV disease was significantly decreased in RIC patients (5.4% versus 20.3%, log rank, P=.04). CMV seropositivity in the patients (P<.01) and corticosteroid administration (P<.01) were revealed by multivariate analysis to be significant risk factors for CMV antigenemia. Grade II-IV aGVHD (P=.02) and grade 3-4 diarrhea before engraftment (P=.04) were revealed to be risk factors for CMV disease. The present study is the first study to show that severe diarrhea before engraftment is a significant risk factor for CMV disease. In summary, risk of CMV disease was significantly decreased in patients without severe mucosal injury of the gut because of the conditioning regimen before engraftment. Biol Blood Marrow Transplant 15: 679-685 (2009) (C) 2009 American Society for Blood and Marrow Transplantation