Effect of plant sterols compared with ezetimibe on oxidative stress in patients treated with statins

被引：3

作者：

Bertolami, Adriana ^{[1
]}

Botelho, Patricia B. ^{[2
]}

Macedo, Luciene F. L. ^{[2
]}

Abdalla, Dulcineia S. F. ^{[3
]}

Faludi, Andre A. ^{[1
]}

Galasso, Melissa ^{[2
]}

Castro, Inar A. ^{[2
]}

机构：

[1] Dante Pazzanese Inst Cardiol, Dyslipidemia Med Sect, Sao Paulo, Brazil

[2] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, LADAF, Sao Paulo, Brazil

[3] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin Anal, Sao Paulo, Brazil

来源：

JOURNAL OF FUNCTIONAL FOODS | 2014年 / 10卷

基金：

巴西圣保罗研究基金会;

关键词：

Chocolate; Ezetimibe; Plant sterol; Statin; Oxidative stress; oxLDL-C; DENSITY-LIPOPROTEIN CHOLESTEROL; LDL-CHOLESTEROL; SIMVASTATIN; PHYTOSTEROLS; METABOLISM; EFFICACY; DISEASE;

D O I：

10.1016/j.jff.2014.05.018

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

This study aimed to compare the action of a drug (ezetimibe) and a functional food containing plant sterol esters on oxidative stress biomarkers. In this double-blind study, 37 type 2 diabetic patients on statin treatment were randomly assigned to receive ezetimibe 10.0 mg/day or to consume a chocolate containing 2.1 g of plant sterol esters for 6 weeks. It was observed that ezetimibe promoted an increase of superoxide dismutase and glutathione reductase activities, while plant sterols did not change these biomarkers. Among individuals who showed the greatest LDL-C and oxLDL-C reduction, the oxLDL-C reduction observed in individuals under plant sterol treatment (-20.0%) did not differ from the values found in individuals treated with ezetimibe (-21.1%). In addition, 16 patients on plant sterol treatment reached the optimal therapeutic goal for LDL-C (<70 mg/dL). Plant sterols added to a non-sugar chocolate bar represent an alternative to statin co-therapy. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：178 / 186

页数：9

共 50 条

[31] l-Carnitine Blood Levels and Oxidative Stress in Treated Phenylketonuric Patients [J].

Sitta, Angela ;

Barschak, Alethea G. ;

Deon, Marion ;

de Mari, Jurema F. ;

Barden, Amanda T. ;

Vanzin, Camila S. ;

Biancini, Giovana B. ;

Schwartz, Ida V. D. ;

Wajner, Moacir ;

Vargas, Carmen R. .

CELLULAR AND MOLECULAR NEUROBIOLOGY, 2009, 29 (02) :211-218

[32] The Effect of Isotretinoin on Oxidative Stress in Severe Acne Vulgaris Patients [J].

Demir, Ahu Yorulmaz ;

Metin, Ahmet ;

Isikoglu, Semra ;

Erel, Ozcan .

TURKIYE KLINIKLERI TIP BILIMLERI DERGISI, 2012, 32 (04) :1026-1031

[33] Potential Cardiovascular Events Avoided with Bempedoic Acid Plus Ezetimibe Fixed-Dose Combination Compared with Ezetimibe Alone in Patients with Atherosclerotic Cardiovascular Disease Taking Maximally Tolerated Statins [J].

McQueen, R. Brett ;

Baum, Seth J. ;

Louie, Michael J. ;

Sasiela, William J. ;

Bilitou, Aikaterini ;

Shah, Hemal ;

Nash, Beth ;

Gillard, Kristin K. ;

Ray, Kausik K. .

AMERICAN JOURNAL OF CARDIOVASCULAR DRUGS, 2023, 23 (01) :67-76

[34] Evaluation of Gamma Irradiation Effect on the Oxidative Stress Factors in Septic Rats Treated With Iranian Plant Essential Oils [J].

Fatemi, Faezeh ;

Yazdi, Atefeh Jalali ;

Ghanooni, Shirin ;

Zolfaghari, Mohammad Reza .

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY, 2018, 61

[35] Effect of losartan, compared with atenolol, on endothelial function and oxidative stress in patients with type 2 diabetes and hypertension [J].

Flammer, Andreas J. ;

Hermann, Frank ;

Wiesli, Peter ;

Schwegler, Beat ;

Chenevard, Remy ;

Huerlimann, David ;

Sudano, Isabella ;

Gay, Steffen ;

Neidhart, Michel ;

Riesen, Walter ;

Ruschitzka, Frank ;

Luescher, Thomas F. ;

Noll, Georg ;

Lehmann, Roger .

JOURNAL OF HYPERTENSION, 2007, 25 (04) :785-791

[36] Evaluation of the combination effect of rutin and vitamin C supplementation on the oxidative stress and inflammation in hemodialysis patients [J].

Omar, Samia ;

El Borolossy, Radwa Maher ;

Elsaid, Tamer ;

Sabri, Nagwa A. .

FRONTIERS IN PHARMACOLOGY, 2022, 13

[37] Oxidative stress and inflammation in mucopolysaccharidosis type IVA patients treated with enzyme replacement therapy [J].

Donida, Bruna ;

Marchetti, Desiree P. ;

Biancini, Giovana B. ;

Deon, Marion ;

Manini, Paula R. ;

da Rosa, Helen T. ;

Moura, Dinara J. ;

Saffi, Jenifer ;

Bender, Fernanda ;

Burin, Maira G. ;

Coitinho, Adriana S. ;

Giugliani, Roberto ;

Vargas, Carmen Regla .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2015, 1852 (05) :1012-1019

[38] Globotriaosylceramide is correlated with oxidative stress and inflammation in Fabry patients treated with enzyme replacement therapy [J].

Biancini, Giovana B. ;

Vanzin, Camila S. ;

Rodrigues, Daiane B. ;

Deon, Marion ;

Ribas, Graziela S. ;

Barschak, Alethea G. ;

Manfredini, Vanusa ;

Netto, Cristina B. O. ;

Jardim, Laura B. ;

Giugliani, Roberto ;

Vargas, Carmen R. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 2012, 1822 (02) :226-232

[39] Oxidative stress in cyclosporin and azathioprine treated renal transplant patients [J].

McGrath, LT ;

Treacy, R ;

McClean, E ;

Brown, JH .

CLINICA CHIMICA ACTA, 1997, 264 (01) :1-12

[40] Oxidative stress related parameters in clozapine treated schizophrenia patients [J].

Stoian, I. ;

Atanasiu, V. ;

Iosif, L. ;

Gaman, L. ;

Panait, E. ;

Gilca, M. .

FREE RADICAL BIOLOGY AND MEDICINE, 2012, 53 :S181-S181

← 1 2 3 4 5 →