Effect of plant sterols compared with ezetimibe on oxidative stress in patients treated with statins

被引：3
作者：
Bertolami, Adriana [1 ]
Botelho, Patricia B. [2 ]
Macedo, Luciene F. L. [2 ]
Abdalla, Dulcineia S. F. [3 ]
Faludi, Andre A. [1 ]
Galasso, Melissa [2 ]
Castro, Inar A. [2 ]
机构：
[1] Dante Pazzanese Inst Cardiol, Dyslipidemia Med Sect, Sao Paulo, Brazil
[2] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, LADAF, Sao Paulo, Brazil
[3] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Clin Anal, Sao Paulo, Brazil
来源：
JOURNAL OF FUNCTIONAL FOODS | 2014年 / 10卷
基金：
巴西圣保罗研究基金会;
关键词：
Chocolate; Ezetimibe; Plant sterol; Statin; Oxidative stress; oxLDL-C; DENSITY-LIPOPROTEIN CHOLESTEROL; LDL-CHOLESTEROL; SIMVASTATIN; PHYTOSTEROLS; METABOLISM; EFFICACY; DISEASE;
D O I：
10.1016/j.jff.2014.05.018
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
This study aimed to compare the action of a drug (ezetimibe) and a functional food containing plant sterol esters on oxidative stress biomarkers. In this double-blind study, 37 type 2 diabetic patients on statin treatment were randomly assigned to receive ezetimibe 10.0 mg/day or to consume a chocolate containing 2.1 g of plant sterol esters for 6 weeks. It was observed that ezetimibe promoted an increase of superoxide dismutase and glutathione reductase activities, while plant sterols did not change these biomarkers. Among individuals who showed the greatest LDL-C and oxLDL-C reduction, the oxLDL-C reduction observed in individuals under plant sterol treatment (-20.0%) did not differ from the values found in individuals treated with ezetimibe (-21.1%). In addition, 16 patients on plant sterol treatment reached the optimal therapeutic goal for LDL-C (<70 mg/dL). Plant sterols added to a non-sugar chocolate bar represent an alternative to statin co-therapy. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：178 / 186
页数：9
相关论文
共 50 条
[21]   Effect of ezetimibe coadministered with statins in genotype-confirmed heterozygous FH patients [J].
Pisciotta, Livia ;
Fasano, Tommaso ;
Bellocchio, Antonella ;
Bocchi, Letizia ;
Sallo, Raffaella ;
Fresa, Raffaele ;
Colangeli, Isabella ;
Cantafora, Alfredo ;
Calandra, Sebastiano ;
Bertolini, Stefano .
ATHEROSCLEROSIS, 2007, 194 (02) :E116-E122
[22]   Effect of ezetimibe/simvastatin compared with atorvastatin on lipoprotein subclasses in patients with type 2 diabetes and hypercholesterolaemia [J].
Tomassini, J. E. ;
Mazzone, T. ;
Goldberg, R. B. ;
Guyton, J. R. ;
Weinstock, R. S. ;
Polis, A. ;
Jensen, E. ;
Tershakovec, A. M. .
DIABETES OBESITY & METABOLISM, 2009, 11 (09) :855-864
[23]   Oxidative stress markers are associated to vascular recurrence in non-cardioembolic stroke patients non-treated with statins [J].
David Brea ;
Jaume Roquer ;
Joaquín Serena ;
Tomás Segura ;
José Castillo .
BMC Neurology, 12
[24]   Effect of plant sterols on the lipid profile of patients with hypercholesterolaemia. Randomised, experimental study [J].
Parraga, Ignacio ;
Lopez-Torres, Jesus ;
Andres, Fernando ;
Navarro, Beatriz ;
del Campo, Jose M. ;
Garcia-Reyes, Mercedes ;
Galdon, Maria P. ;
Lloret, Angeles ;
Precioso, Juan C. ;
Rabanales, Joseba .
BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2011, 11
[25]   Effect of bempedoic acid plus ezetimibe fixed-dose combination vs ezetimibe or placebo on low-density lipoprotein cholesterol in patients with type 2 diabetes and hypercholesterolemia not treated with statins [J].
Bays, Harold E. ;
Baum, Seth J. ;
Brinton, Eliot A. ;
Plutzky, Jorge ;
Hanselman, Jeffrey C. ;
Teng, Rujun ;
Ballantyne, Christie M. .
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY, 2021, 8
[26]   Oxidative stress assessment in sickle cell anemia patients treated with hydroxyurea [J].
Reno, Cristiane O. ;
Barbosa, Amanda Rodrigues ;
de Carvalho, Sara Santos ;
Pinheiro, Melina B. ;
Rios, Danyelle Romana ;
Cortes, Vanessa F. ;
Barbosa, Leandro A. ;
Santos, Herica L. .
ANNALS OF HEMATOLOGY, 2020, 99 (05) :937-945
[27]   Ezetimibe Combined With Simvastatin Compared With Simvastatin Alone Results in a Greater Suppression of Oxidative Stress and Enhanced Fibrinolysis in Patients After Acute Coronary Events [J].
Undas, Anetta ;
Machnik, Andrzej ;
Potaczek, Daniel P. ;
Wypasek, Ewa ;
Zmudka, Krzysztof ;
Tracz, Wieslawa .
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY, 2011, 58 (02) :167-172
[28]   Investigation of oxidative stress parameters in treated phenylketonuric patients [J].
A. Sitta ;
A. G. Barschak ;
M. Deon ;
T. Terroso ;
R. Pires ;
R. Giugliani ;
C. S. Dutra-Filho ;
M. Wajner ;
C. R. Vargas .
Metabolic Brain Disease, 2006, 21 :287-296
[29]   Investigation of oxidative stress parameters in treated phenylketonuric patients [J].
Sitta, A. ;
Barschak, A. G. ;
Deon, M. ;
Terroso, T. ;
Pires, R. ;
Giugliani, R. ;
Dutra-Filho, C. S. ;
Wajner, M. ;
Vargas, C. R. .
METABOLIC BRAIN DISEASE, 2006, 21 (04) :287-296
[30]   Association between creatine kinase activity, oxidative stress and selenoproteins mRNA expression changes after Brazil nut consumption of patients using statins [J].
Watanabe, Ligia Moriguchi ;
de Lima, Livia Fernandes ;
Ferraz-Bannitz, Rafael ;
Takaara, Daniela ;
Romano, Beatriz Coimbra ;
Braga Costa, Telma Maria ;
Foss de Freitas, Maria Cristina ;
Bueno, Ana Carolina ;
Barbosa Junior, Fernando ;
Navarro, Anderson Marliere .
CLINICAL NUTRITION, 2020, 39 (10) :3175-3181
12345