Analysis of epistasis for diabetic nephropathy among type 2 diabetic patients

被引：21
作者：
Hsieh, Chang-Hsun
Liang, Kung-Hao
Hung, Yi-Jen
Huang, Li-Chin
Pei, Dee
Liao, Ya-Tang
Kuo, Shi-Wen
Bey, Monica Shian-Jy
Chen, Jui-Lin
Chen, Ellson Y.
机构：
[1] Vita Genom Inc, Taipei 248, Taiwan
[2] Tri Serv Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, Taipei, Taiwan
[3] Xindian Buddhist Tzu Chi Hosp, Dept Internal Med, Taipei, Taiwan
来源：
HUMAN MOLECULAR GENETICS | 2006年 / 15卷 / 18期
关键词：
D O I：
10.1093/hmg/ddl203
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetic nephropathy (DN) is one of the most serious complications of diabetes, accounting for the majority of patients with end-stage renal disease. The molecular pathogenesis of DN involves multiple pathways in a complex, partially resolved manner. The paper presents an exploratory epistatic study for DN. Association analysis were performed on 231 SNP loci in a cohort of 264 type 2 diabetes patients, followed by the epistasis analysis using the multifactor dimensionality reduction and the genetic algorithm with Boolean algebra. A two-locus epistatic effect of EGFR and RXRG was identified, with a cross-validation consistency of 91.7%.
引用
收藏
页码：2701 / 2708
页数：8
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