A facile synthesis of 3-trifluoromethyl-1,2,4-oxadiazoles from cyanamides

被引：19

作者：

Goldberg, Kristin ^{[1
]}

Clarke, David S. ^{[1
]}

Scott, James S. ^{[1
]}

机构：

[1] AstraZeneca, Cardiovasc & Gastrointestinal Innovat Med Unit, Macclesfield SK10 4TG, Cheshire, England

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 32期

关键词：

3-Trifluoromethyl-1,2,4-oxadiazoles; Cyanamides; N-Boc-hydroxylamine; 1,2,4-Oxadiazoles; NITRILE OXIDES; CYCLOADDITION; OPTIMIZATION;

D O I：

10.1016/j.tetlet.2014.06.019

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A safe and facile method for the formation of 3-trifluoromethyl-5-amino-1,2,4-oxadiazoles, via a reversed addition of hydroxylamine to cyanamides, is reported. This two-pot procedure is suitable to scale-up and avoids the hazards associated with trifluoromethyl amidoxime synthesis. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：4433 / 4436

页数：4

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