Global analysis of bacterial transcription factors to predict cellular target processes

被引：12

作者：

Doerks, T

Andrade, MA

Lathe, W

von Mering, C

Bork, P

机构：

[1] EMBL, D-69117 Heidelberg, Germany

[2] Max Delbrueck Cent, Berlin, Germany

[3] Ottawa Hlth Res Inst, Ottawa, ON K1H 8L6, Canada

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 03期

关键词：

D O I：

10.1016/j.tig.2004.01.006

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Whole-genome sequences are now available for >100 bacterial species, giving unprecedented power to comparative genomics approaches. We have applied genome-context methods to predict target processes that are regulated by transcription factors (TFs). Of 128 orthologous groups of proteins annotated as TFs, to date, 36 are functionally uncharacterized; in our analysis we predict a probable cellular target process or biochemical pathway for half of these functionally uncharacterized TFs.

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页码：126 / 131

页数：6

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