A-420983: a potent, orally active inhibitor of lck with efficacy in a model of transplant rejection

被引：34

作者：

Borhani, DW ^{[1
]}

Calderwood, DJ ^{[1
]}

Friedman, MM ^{[1
]}

Hirst, GC ^{[1
]}

Li, BQ ^{[1
]}

Leung, AKW ^{[1
]}

McRae, B ^{[1
]}

Ratnofsky, S ^{[1
]}

Ritter, K ^{[1
]}

Waegell, W ^{[1
]}

机构：

[1] Abbott Biores Ctr, Worcester, MA 01605 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 10期

关键词：

D O I：

10.1016/j.bmcl.2004.02.101

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have identified the pyrazolo[3,4-d]pyrimidine A-420983 (compound 7) as a potent inhibitor of lck. A-420983 exhibits oral efficacy in animal models of delayed-type hypersensitivity and organ transplant rejection. (C) 2004 Elsevier Ltd. All rights reserved.

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页码：2613 / 2616

页数：4

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