Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis

被引：410

作者：

Erdogan, Begum ^{[1
]}

Webb, Donna J. ^{[1
,2
,3
]}

机构：

[1] Vanderbilt Univ, Dept Biol Sci, VU Stn B,Box 35-1634, Nashville, TN 37235 USA

[2] Vanderbilt Univ, Vanderbilt Kennedy Ctr Res Human Dev, Nashville, TN 37235 USA

[3] Vanderbilt Univ, Dept Canc Biol, 221 Kirkland Hall, Nashville, TN 37235 USA

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2017年 / 45卷

基金：

美国国家卫生研究院;

关键词：

EPITHELIAL-MESENCHYMAL TRANSITION; CARCINOMA-ASSOCIATED FIBROBLASTS; CELL-MIGRATION; TRANSFORMING GROWTH-FACTOR-BETA-1; IN-VITRO; INVASION; MICROENVIRONMENT; PATHWAYS; PROMOTE; EXPRESSION;

D O I：

10.1042/BST20160387

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cancer-associated fibroblasts (CAFs) are major components of the surrounding stroma of carcinomas that emerge in the tumor microenvironment as a result of signals derived from the cancer cells. Biochemical cross-talk between cancer cells and CAFs as well as mechanical remodeling of the stromal extracellular matrix (ECM) by CAFs are important contributors to tumor cell migration and invasion, which are critical for cancer progression from a primary tumor to metastatic disease. In this review, we discuss key paracrine signaling pathways between CAFs and cancer cells that promote cancer cell migration and invasion. In addition, we discuss physical changes that CAFs exert on the stromal ECM to facilitate migration and invasion of cancer cells.

引用

页码：229 / 236

页数：8

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