Histone Demethylases and Cancer

被引：45

作者：

Kampranis, Sotirios C. ^{[1
]}

Tsichlis, Philip N. ^{[1
]}

机构：

[1] Tufts Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA

来源：

ADVANCES IN CANCER RESEARCH, VOL 102 | 2009年 / 102卷

关键词：

MYC TARGET GENE; LINKED MENTAL-RETARDATION; TUMOR-SUPPRESSOR GENE; GENOME-WIDE ANALYSIS; GROUP PROTEIN EZH2; RNA-POLYMERASE-II; POLYCOMB GROUP; ARGININE METHYLATION; JMJC-DOMAIN; TRANSCRIPTIONAL REPRESSION;

D O I：

10.1016/S0065-230X(09)02004-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Epigenetic modifications are heritable chromatin alterations that contribute to the temporal and spatial interpretation of the genome. The epigenetic information is conveyed through a multitude of chemical modifications including DNA methylation, reversible modifications of histones, and ATP-dependent nucleosomal remodeling. Deregulation of the epigenetic machinery contributes to the development of several pathologies, including cancer. Chromatin modifications are multiple and interdependent and they are dynamically modulated in the course of various biological processes. Combinations of chromatin modifications give rise to a complex code that is superimposed on the genetic code embedded into the DNA sequence to regulate cell function. This review addresses the rote of epigenetic modifications in cancer, focusing primarily on histone methylation marks and the enzymes catalyzing their removal. (C) 2009 Elsevier Inc.

引用

页码：103 / 169

页数：67

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