The enhancer shift: a model to explain the developmental control of IgH gene expression in B-lineage cells

被引：29
作者：
Arulampalam, V
Eckhardt, L
Pettersson, S
机构：
[1] CUNY HUNTER COLL,DEPT BIOL SCI,NEW YORK,NY 10021
[2] KAROLINSKA INST,DEPT BIOSCI,S-14157 HUDDINGE,SWEDEN
来源：
IMMUNOLOGY TODAY | 1997年 / 18卷 / 11期
关键词：
D O I：
10.1016/S0167-5699(97)01154-7
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The roles attributed to the E mu enhancer and the downstream 3' regions acting as locus control regions (LCRs) have allowed comparisons to be drawn between regulation of the IgH locus in early and late B-cell development and other systems governed by LCR activity. Here, the importance of the IgH 3'LCR and its putative functional role in the control of IgH gene expression is evaluated and compared with the 5'LCR regulatory region of the human beta-globin locus.
引用
收藏
页码：549 / 554
页数：6
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