Uncovering the roles of long non-coding RNAs in cancer stem cells

被引：66
作者：
Huang, Xiaoxing [1 ]
Xiao, Ruijing [1 ]
Pan, Shan [1 ]
Yang, Xiangyong [2 ]
Yuan, Wen [1 ]
Tu, Zhenbo [1 ]
Xu, Ming [1 ]
Zhu, Yufan [1 ]
Yin, Qian [1 ]
Wu, Yingjie [1 ]
Hu, Weidong [3 ]
Shao, Liang [4 ]
Xiong, Jie [1 ]
Zhang, Qiuping [1 ]
机构：
[1] Wuhan Univ, Sch Basic Med Sci, Dept Immunol, Wuhan 430071, Peoples R China
[2] Hubei Univ Technol, Engn & Technol Coll, Wuhan 430000, Peoples R China
[3] Wuhan Univ, Zhongnan Hosp, Dept Oncol, Wuhan 430071, Peoples R China
[4] Wuhan Univ, Zhongnan Hosp, Dept Hematol, Wuhan 430071, Peoples R China
来源：
JOURNAL OF HEMATOLOGY & ONCOLOGY | 2017年 / 10卷
基金：
中国国家自然科学基金;
关键词：
Long non-coding RNAs; Cancer stem cells; Self-renewal; Malignant transformation; Tumor metastasis; Tumor recurrence; BREAST-CANCER; DOWN-REGULATION; POOR-PROGNOSIS; DECREASED EXPRESSION; ANDROGEN RECEPTOR; GASTRIC-CANCER; INVASION; GROWTH; METASTASIS; MECHANISMS;
D O I：
10.1186/s13045-017-0428-9
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancer has been a major public health problem that has threatened human life worldwide throughout history. The main causes that contribute to the poor prognosis of cancer are metastasis and recurrence. Cancer stem cells are a group of tumor cells that possess self-renewal and differentiation ability, which is a vital cause of cancer metastasis and recurrence. Long non-coding RNAs refer to a class of RNAs that are longer than 200 nt and have no potential to code proteins, some of which can be specifically expressed in different tissues and different tumors. Long non-coding RNAs have great biological significance in the occurrence and progression of cancers. However, how long non-coding RNAs interact with cancer stem cells and then affect cancer metastasis and recurrence is not yet clear. Therefore, this review aims to summarize recent studies that focus on how long non-coding RNAs impact tumor occurrence and progression by affecting cancer stem cell self-renewal and differentiation in liver cancer, prostate cancer, breast cancer, and glioma.
引用
收藏
页数：9
相关论文
共 67 条
[1]   Brief Report: The lincRNA Hotair Is Required for Epithelial-to-Mesenchymal Transition and Stemness Maintenance of Cancer Cell Lines [J].
Alves, Cleidson Padua ;
Fonseca, Aline Simoneti ;
Muys, Bruna Rodrigues ;
Bueno, Rafaela de Barros e Lima ;
Buerger, Matheus Carvalho ;
de Souza, Jorge E. S. ;
Valente, Valeria ;
Zago, Marco Antonio ;
Silva, Wilson Araujo, Jr. .
STEM CELLS, 2013, 31 (12) :2827-2832
[2]   Enrichment of Human Stem-Like Prostate Cells with s-SHIP Promoter Activity Uncovers a Role in Stemness for the Long Noncoding RNA H19 [J].
Bauderlique-Le Roy, Helene ;
Vennin, Constance ;
Brocqueville, Guillaume ;
Spruyt, Nathalie ;
Adriaenssens, Eric ;
Bourette, Roland P. .
STEM CELLS AND DEVELOPMENT, 2015, 24 (10) :1252-1262
[3]   Identifying and targeting cancer stem cells in the treatment of gastric cancer [J].
Bekaii-Saab, Tanios ;
El-Rayes, Bassel .
CANCER, 2017, 123 (08) :1303-1312
[4]   Global identification of human transcribed sequences with genome tiling arrays [J].
Bertone, P ;
Stolc, V ;
Royce, TE ;
Rozowsky, JS ;
Urban, AE ;
Zhu, XW ;
Rinn, JL ;
Tongprasit, W ;
Samanta, M ;
Weissman, S ;
Gerstein, M ;
Snyder, M .
SCIENCE, 2004, 306 (5705) :2242-2246
[5]   High Expression of H3K27me3 in Human Hepatocellular Carcinomas Correlates Closely with Vascular Invasion and Predicts Worse Prognosis in Patients [J].
Cai, Mu-Yan ;
Hou, Jing-Hui ;
Rao, Hui-Lan ;
Luo, Rong-Zhen ;
Li, Mei ;
Pei, Xiao-Qing ;
Lin, Marie C. ;
Guan, Xin-Yuan ;
Kung, Hsiang-Fu ;
Zeng, Yi-Xin ;
Xie, Dan .
MOLECULAR MEDICINE, 2011, 17 (1-2) :12-20
[6]   Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver [J].
Chang, C. ;
Lee, S. O. ;
Yeh, S. ;
Chang, T. M. .
ONCOGENE, 2014, 33 (25) :3225-3234
[7]   Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution [J].
Cheng, J ;
Kapranov, P ;
Drenkow, J ;
Dike, S ;
Brubaker, S ;
Patel, S ;
Long, J ;
Stern, D ;
Tammana, H ;
Helt, G ;
Sementchenko, V ;
Piccolboni, A ;
Bekiranov, S ;
Bailey, DK ;
Ganesh, M ;
Ghosh, S ;
Bell, I ;
Gerhard, DS ;
Gingeras, TR .
SCIENCE, 2005, 308 (5725) :1149-1154
[8]  
Clarke Michael F, 2006, Cancer Res, V66, P9339, DOI 10.1158/0008-5472.CAN-06-3126
[9]   CD90+liver cancer cells modulate endothelial cell phenotype through the release of exosomes containing H19 lncRNA [J].
Conigliaro, Alice ;
Costa, Viviana ;
Lo Dico, Alessia ;
Saieva, Laura ;
Buccheri, Simona ;
Dieli, Francesco ;
Manno, Mauro ;
Raccosta, Samuele ;
Mancone, Carmine ;
Tripodi, Marco ;
De Leo, Giacomo ;
Alessandro, Riccardo .
MOLECULAR CANCER, 2015, 14
[10]   Cancer stem cells: Models and concepts [J].
Dalerba, Piero ;
Cho, Robert W. ;
Clarke, Michael F. .
ANNUAL REVIEW OF MEDICINE, 2007, 58 :267-284
1234567