Palladium-Catalyzed Carbonylative Annulation Reactions Using Aryl Formate as a CO Source: Synthesis of 2-Substituted Indene-1,3(2H)-dione Derivatives

被引：19

作者：

Zhang, Ying ^{[1
]}

Chen, Jing-Lei ^{[1
]}

Chen, Zhen-Bang ^{[1
]}

Zhu, Yong-Ming ^{[1
]}

Ji, Shun-Jun ^{[2
]}

机构：

[1] Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China

[2] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 21期

关键词：

DEPENDENT KINASE INHIBITORS; BUTYL ISOCYANIDE INSERTION; VINYLIC HALIDES; CARBON-MONOXIDE; CYCLIZATION REACTIONS; COUPLING REACTIONS; N-FORMYLSACCHARIN; PHENYL FORMATE; EFFICIENT; ALKOXYCARBONYLATION;

D O I：

10.1021/acs.joc.5b01758

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of 2-substituted indene-1,3(2H)-diones from stable and readily available 1-(2-halophenyl)-1,3-diones by employing phenyl formate as a CO source has been developed. The reaction occurred via palladium-catalyzed intramolecular carbonylative annulation using K3PO4 as a base and DMSO as a solvent at 95 degrees C. In this protocol, the reaction showed a broad substrate scope with good to excellent yields.

引用

页码：10643 / 10650

页数：8

共 32 条

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