Ubiquitin in the immune system

被引：196
作者：
Zinngrebe, Julia [1 ]
Montinaro, Antonella [1 ]
Peltzer, Nieves [1 ]
Walczak, Henning [1 ]
机构：
[1] UCL, UCL Canc Inst, Ctr Cell Death Canc & Inflammat CCCI, London, England
来源：
EMBO REPORTS | 2014年 / 15卷 / 01期
基金：
英国惠康基金; 瑞士国家科学基金会;
关键词：
autoimmunity; DUBs; E3; ligases; inflammation; LUBAC; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; CHRONIC PROLIFERATIVE DERMATITIS; T-CELL-ACTIVATION; RIG-I; CBL-B; LINEAR UBIQUITINATION; TNF RECEPTOR; DEUBIQUITINATING ENZYME; NEGATIVE REGULATION;
D O I：
10.1002/embr.201338025
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ubiquitination is a post-translational modification process that has been implicated in the regulation of innate and adaptive immune responses. There is increasing evidence that both ubiquitination and its reversal, deubiquitination, play crucial roles not only during the development of the immune system but also in the orchestration of an immune response by ensuring the proper functioning of the different cell types that constitute the immune system. Here, we provide an overview of the latest discoveries in this field and discuss how they impact our understanding of the ubiquitin system in host defence mechanisms as well as self-tolerance.
引用
收藏
页码：28 / 45
页数：18
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