Building new function into glycine receptors: A structural model for the activation of the glycine-gated chloride channel

被引：4
作者：
Lynch, JW [1 ]
Han, NLR
Schofield, PR
机构：
[1] Univ Queensland, Dept Physiol & Pharmacol, St Lucia, Qld 4072, Australia
[2] Garvan Inst Med Res, Neurobiol Program, Darlinghurst, NSW, Australia
来源：
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY | 1999年 / 26卷 / 11期
关键词：
beta-alanine; hyperekplexia; ligand-gated ion channel; structure-function; taurine;
D O I：
10.1046/j.1440-1681.1999.03150.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
1, The glycine receptor chloride channel mediates inhibitory neurotransmission and is a member of the ligand-gated ion channel superfamilyl which includes the nicotinic acetylcholine receptor channel. 2, Activation of these channels involves a movement of the pore-lining second membrane-spanning domain with respect to the remainder of the protein. 3, The present review considers the evidence that the loops that connect this domain with the rest of the protein act as crucial components of the channel activation mechanism.
引用
收藏
页码：932 / 934
页数：3
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