Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) in humans with multiple sclerosis

被引：16

作者：

Baranowska-Bik, Agnieszka ^{[1
]}

Kochanowski, Jan ^{[2
]}

Uchman, Dorota ^{[2
]}

Wolinska-Witort, Ewa ^{[3
]}

Kalisz, Malgorzata ^{[3
]}

Martynska, Lidia ^{[3
]}

Baranowska, Boguslawa ^{[4
]}

Bik, Wojciech ^{[3
]}

机构：

[1] Bielanski Hosp, Med Ctr Postgrad Educ, Dept Endocrinol, PL-01809 Warsaw, Poland

[2] Med Univ Warsaw, Bielanski Hosp, Dept Neurol, PL-01809 Warsaw, Poland

[3] Med Ctr Postgrad Educ, Dept Neuroendocrinol, PL-01813 Warsaw, Poland

[4] Med Ctr Postgrad Educ, Dept Clin Physiol, PL-01813 Warsaw, Poland

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2013年 / 263卷 / 1-2期

关键词：

VIP; PACAP; Multiple sclerosis; IL-6; TNF alpha; IL-10; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; CELLS; EXPRESSION; DISEASE; T(H)1;

D O I：

10.1016/j.jneuroim.2013.08.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Multiple sclerosis (MS) is a chronic neuroinflammatory disease of the central nervous system that leads to demyelination and neurodegeneration. VIP and PACAP are structurally related neuropeptides with neuroprotective and anti-inflammatory activities. To evaluate VIP and PACAP-38 in plasma and CSF in humans in correlation with IL-6, IL-10 and TNF alpha we compared 20 MS individuals with 27 healthy controls. In MS, a decrease in PACAP-38 in CSF and a decrease in plasma IL-6 concentration were seen. A positive correlation between plasma VIP and plasma IL-6 was identified. We conclude that VIP and PACAP may influence the course of MS. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：159 / 161

页数：3

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