Peripheral CD4+T cells showing a Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion

被引：85

作者：

Miyake, Katsuhisa ^{[1
]}

Moriyama, Masafumi ^{[2
]}

Aizawa, Kumiko ^{[1
]}

Nagano, Shuji ^{[1
]}

Inoue, Yasushi ^{[1
]}

Sadanaga, Atsushi ^{[1
]}

Nakashima, Hitoshi ^{[1
]}

Nakamura, Seiji ^{[2
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Med & Biosyst Sci, Higashi Ku, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Dent Sci, Dept Oral & Maxillofacial Surg, Fukuoka 8128582, Japan

来源：

MODERN RHEUMATOLOGY | 2008年 / 18卷 / 01期

关键词：

Mikulicz's disease; Sjogren's syndrome; Th1/Th2; balance;

D O I：

10.1007/s10165-007-0010-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mikulicz's disease (MD) is a unique IgG4-related systemic disease indicated by enlargement of the lachrymal and salivary glands and which differs substantially from Sjogren's syndrome. A male patient with pleural effusion, swelling of the submandibular glands, and swelling of the paraaortic, mediastinal, and pararenal lymph nodes was diagnosed with MD. Analysis of peripheral CD4+ T cells from the patient revealed deviation of the Th1/Th2 balance to Th2. Prednisolone therapy ameliorated the disease and corrected the Th1/Th2 imbalance.

引用

页码：86 / 90

页数：5

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