Synthesis of highly enantio-enriched stereoisomers of hydroxy-GR24

被引：13

作者：

Morris, J. C. ^{[1
]}

McErlean, C. S. P. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 04期

基金：

澳大利亚研究理事会;

关键词：

INTRAMOLECULAR 2+2 CYCLOADDITION; STRIGOLACTONE ANALOGS; BIOLOGICAL-ACTIVITY; OROBANCHE-CUMANA; PLANT HORMONES; GERMINATION; STRIGA; SEEDS; RHIZOSPHERE; MOLECULES;

D O I：

10.1039/c5ob02349a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In contrast to a biomimetic electrophilic cyclisation cascade, we employ a contra-biomimetic nucleophilic cyclisation cascade to give the tricyclic core of 4-hydroxy-GR24 in a single step. Kinetic resolution using a stereoselective Noyori transfer hydrogenation enables the concise synthesis of any enantiomerically enriched 4-hydroxy-GR24 stereoisomer.

引用

收藏

页码：1236 / 1238

页数：3

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