Linguistic and Non-Linguistic Semantic Processing in Individuals with Autism Spectrum Disorders: An ERP Study

被引：42
作者：
Coderre, Emily L. [1 ]
Chernenok, Mariya [1 ,2 ]
Gordon, Barry [1 ,3 ]
Ledoux, Kerry [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Div Cognit Neurol Neuropsychol, Baltimore, MD 21205 USA
[2] Univ Calif Davis, Ctr Mind & Brain, Davis, CA 95616 USA
[3] Johns Hopkins Univ, Dept Cognit Sci, Baltimore, MD 21218 USA
来源：
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS | 2017年 / 47卷 / 03期
关键词：
Autism spectrum disorders; Semantic processing; ERP; Language; Pictures; EVENT-RELATED POTENTIALS; HIGH-FUNCTIONING AUTISM; SENTENCE COMPREHENSION; BRAIN POTENTIALS; PICTURES; LANGUAGE; CONNECTIVITY; N400; CHILDREN; WORDS;
D O I：
10.1007/s10803-016-2985-0
中图分类号：
B844 [发展心理学（人类心理学）];
学科分类号：
040202 ;
摘要：
Individuals with autism spectrum disorders (ASD) experience difficulties with language, particularly higher-level functions like semantic integration. Yet some studies indicate that semantic processing of non-linguistic stimuli is not impaired, suggesting a language-specific deficit in semantic processing. Using a semantic priming task, we compared event-related potentials (ERPs) in response to lexico-semantic processing (written words) and visuosemantic processing (pictures) in adults with ASD and adults with typical development (TD). The ASD group showed successful lexico-semantic and visuo-semantic processing, indicated by similar N400 effects between groups for word and picture stimuli. However, differences in N400 latency and topography in word conditions suggested different lexico-semantic processing mechanisms: an expectancy-based strategy for the TD group but a controlled post-lexical integration strategy for the ASD group.
引用
收藏
页码：795 / 812
页数：18
相关论文
共 59 条
[11]   Task- related functional connectivity in autism spectrum conditions: an EEG study using wavelet transform coherence [J].
Catarino, Ana ;
Andrade, Alexandre ;
Churches, Owen ;
Wagner, Adam P. ;
Baron-Cohen, Simon ;
Ring, Howard .
MOLECULAR AUTISM, 2013, 4
[12]   Overlap and dissociation of semantic processing of Chinese characters, English words, and pictures: Evidence from fMRI [J].
Chee, MWL ;
Weekes, B ;
Lee, KM ;
Soon, CS ;
Schreiber, A ;
Hoon, JJ ;
Chee, M .
NEUROIMAGE, 2000, 12 (04) :392-403
[13]   Functional connectivity in a baseline resting-state network in autism [J].
Cherkassky, Vladimir L. ;
Kana, Rajesh K. ;
Keller, Timothy A. ;
Just, Marcel Adam .
NEUROREPORT, 2006, 17 (16) :1687-1690
[14]   EEG power and coherence in autistic spectrum disorder [J].
Coben, Robert ;
Clarke, Adam R. ;
Hudspeth, William ;
Barry, Robert J. .
CLINICAL NEUROPHYSIOLOGY, 2008, 119 (05) :1002-1009
[15]   Is "Blank" a suitable neutral prime for event-related potential experiments? [J].
Dien, J ;
Franklin, MS ;
May, CJ .
BRAIN AND LANGUAGE, 2006, 97 (01) :91-101
[16]   Electrophysiologic correlates of semantic classification in autistic and normal children [J].
Dunn, M ;
Vaughan, H ;
Kreuzer, J ;
Kurtzberg, D .
DEVELOPMENTAL NEUROPSYCHOLOGY, 1999, 16 (01) :79-99
[17]   Developmental change in neutral processing of words by children with autism [J].
Dunn, MA ;
Bates, JC .
JOURNAL OF AUTISM AND DEVELOPMENTAL DISORDERS, 2005, 35 (03) :361-376
[18]   Semantic priming modulates the N400, N300, and N400RP [J].
Franklin, Michael S. ;
Dien, Joseph ;
Neely, James H. ;
Huber, Elizabeth ;
Waterson, Lauren D. .
CLINICAL NEUROPHYSIOLOGY, 2007, 118 (05) :1053-1068
[19]   Frontal and posterior sources of event-related potentials in semantic comprehension [J].
Frishkoff, GA ;
Tucker, DM ;
Davey, C ;
Scherg, M .
COGNITIVE BRAIN RESEARCH, 2004, 20 (03) :329-354
[20]   Hemispheric differences in strong versus weak semantic priming: Evidence from event-related brain potentials [J].
Frishkoff, Gwen A. .
BRAIN AND LANGUAGE, 2007, 100 (01) :23-43
123456