Competition controls the rate of transition between the peripheral pools of CD4+CD25- and CD4+CD25+ T cells

被引:17
作者
Almeida, Afonso R. M. [1 ]
Zaragoza, Bruno [1 ]
Freitas, Antonio A. [1 ]
机构
[1] Inst Pasteur, Lymphocyte Populat Biol Unit, CNRS, URA 1961, F-75015 Paris, France
关键词
IL-2; lymphopenia; driven proliferation; regulatory T cells; T-cell homeostasis;
D O I
10.1093/intimm/dxl093
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Recent reports have hinted that it is possible to regenerate CD4(+)CD25(+) regulatory T cells (Treg) from CD4(+)CD25(-) cells, a phenomenon termed conversion. We evaluated the relative contribution of this process to the Treg pool by transferring purified populations of CD4(+) T cells into T cell-deficient mice. We report that conversion of CD25(-) cells into the CD4(+)CD25(+)Treg pool is minor if other bona fide CD25(+) Tregs are present. Moreover, in the same hosts, the loss of CD25 expression by a population of Tregs also decreases in the presence of co-injected CD4(+)CD25(-) cells. Thus, the rate of exchange between CD25(-) and CD25(+) T-cell populations is determined by the presence or absence of T-cell competitors. Our results attest for the role of competition in the contribution of different T-cell subsets for the regeneration of the peripheral CD4(+) T-cell pool during lymphopenia.
引用
收藏
页码:1607 / 1613
页数:7
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