Horseradish peroxidase-catalyzed hydrogelation for biomedical applications

被引:125
作者
Khanmohammadi, Mehdi [1 ]
Dastjerdi, Mahsa Borzouyan [2 ]
Ai, Arman [3 ]
Ahmadi, Akbar [4 ]
Godarzi, Arash [1 ]
Rahimi, Azam [1 ]
Ai, Jafar [1 ]
机构
[1] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Tissue Engn & Appl Cell Sci, Tehran, Iran
[2] Natl Inst Genet Engn & Biotechnol, Inst Med Biotechnol, Tehran, Iran
[3] Univ Tehran Med Sci, Sch Med, Tehran, Iran
[4] Univ Tehran Med Sci, Sch Adv Technol Med, Dept Neurosci, Tehran, Iran
关键词
SITU FORMING HYDROGELS; CHITOSAN-BASED HYDROGELS; ENZYMATIC CROSS-LINKING; IN-SITU; HYALURONIC-ACID; CELL ENCAPSULATION; GELATIN HYDROGELS; INJECTABLE HYDROGEL; POLY(VINYL ALCOHOL); TYRAMINE HYDROGELS;
D O I
10.1039/c8bm00056e
中图分类号
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号
0805 ; 080501 ; 080502 ;
摘要
Hydrogels catalyzed by horseradish peroxidase (HRP) serve as an efficient and effective platform for biomedical applications due to their mild reaction conditions for cells, fast and adjustable gelation rate in physiological conditions, and an abundance of substrates as water-soluble biocompatible polymers. In this review, we highlight the tunable characteristics and use of the HRP-catalyzed hydrogels and provide a brief overview of various substrates employed in the HRP system for different biomedical applications of the resultant hydrogels. In addition, we discuss and summarize the biocompatibility, possible functionalization, and biofabrication process. Finally, the future prospective of the HRP crosslinking system is highlighted with biomedical applications.
引用
收藏
页码:1286 / 1298
页数:13
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