Antiviral evaluation of N-amino-1,2,3-triazoles against Cantagalo virus replication in cell culture

被引：119

作者：

Jordao, Alessandro K. ^{[1
]}

Afonso, Priscila P. ^{[2
]}

Ferreira, Vitor F. ^{[1
]}

de Souza, Maria C. B. V. ^{[1
]}

Almeida, Maria C. B. ^{[1
]}

Beltrame, Cristiana O. ^{[2
]}

Paiva, Daniel P. ^{[2
]}

Wardell, Solange M. S. V. ^{[3
]}

Wardell, James L. ^{[4
,5
]}

Tiekink, Edward R. T. ^{[6
]}

Damaso, Clarissa R. ^{[2
]}

Cunha, Anna C. ^{[1
]}

机构：

[1] Univ Fed Fluminense, Dept Quim Organ, Inst Quim, BR-24020141 Niteroi, RJ, Brazil

[2] Univ Fed Rio de Janeiro, Lab Biol Mol Virus, Inst Biofis Carlos Chagas Filho, CCS, BR-21949900 Rio De Janeiro, Brazil

[3] FAR MANGUINHOS, BR-21041250 Rio De Janeiro, Brazil

[4] Univ Aberdeen, Dept Chem, Old Aberdeen AB24 3UE, Scotland

[5] Fiocruz MS, CDTS, BR-21040900 Rio De Janeiro, Brazil

[6] Univ Texas San Antonio, Dept Chem, San Antonio, TX 78248 USA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2009年 / 44卷 / 09期

关键词：

1,2,3-Triazole derivatives; Diazo compounds; Cantagalo virus; Anti-poxvirus agents; Molecular structure; X-ray crystallography; RIO-DE-JANEIRO; POXVIRUS INFECTIONS; SUBSTITUTED 1,2,3-TRIAZOLES; SMALLPOX VACCINE; IN-VITRO; DERIVATIVES; CATTLE; AGENTS; CYCLOADDITION; CHEMISTRY;

D O I：

10.1016/j.ejmech.2009.04.046

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This paper describes the antiviral evaluation of new N-amino-1,2,3-triazole derivatives, 1-(substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid ethyl esters, 3 and 1-(4-substituted-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazides, 4, on Cantagalo virus replication. 1-(4-Fluoro-phenylamino)-5-methyl-1H-[1,2,3]-triazole-4-carboxylic acid hydrazide, 4e, exhibited a significant antiviral effect. Characterization of all compounds was confirmed by IR, H-1 and C-13 spectroscopies and elemental analysis. In addition, molecular structure of 4e was also reported. (C) 2009 Elsevier Masson SAS. All rights reserved.

引用

页码：3777 / 3783

页数：7

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