Combinatorial Biomolecular Nanopatterning for High-Throughput Screening of Stem-Cell Behavior

被引：16

作者：

Amin, Yacoub Y. I. ^{[1
]}

Runager, Kasper ^{[1
]}

Simoes, Fabio ^{[2
]}

Celiz, Adam ^{[2
]}

Taresco, Vincenzo ^{[2
]}

Rossi, Roberto ^{[3
]}

Enghild, Jan J. ^{[1
]}

Abildtrup, Lisbeth A. ^{[4
]}

Kraft, David C. E. ^{[4
]}

Sutherland, Duncan S. ^{[1
]}

Alexander, Morgan R. ^{[2
]}

Foss, Morten ^{[1
]}

Ogaki, Ryosuke ^{[1
]}

机构：

[1] Aarhus Univ, Fac Sci & Technol, Interdisciplinary Nanosci Ctr iNANO, DK-8000 Aarhus C, Denmark

[2] Univ Nottingham, Sch Pharm, Lab Biophys & Surface Anal, Nottingham NG7 2RD, England

[3] Univ Padua, Dept Chem Sci, I-35122 Padua, Italy

[4] Aarhus Univ, Fac Hlth, Dept Dent, DK-8000 Aarhus C, Denmark

来源：

ADVANCED MATERIALS | 2016年 / 28卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

cell adhesion; combinatorial; high throughput; nanofabrication; protein patterning; FATE; MICROENVIRONMENTS; DIFFERENTIATION; 3RD-DIMENSION; BIOMATERIALS; CULTURE;

D O I：

10.1002/adma.201504995

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel combinatorial biomolecular nanopatterning method is reported, in which multiple biomolecular ligands can be patterned in multiple nanoscale dimensions on a single surface. The applicability of the combinatorial platform toward cell-biology applications is demonstrated by screening the adhesion behavior of a population of human dental pulp stem cell (hDPSC) on 64 combinations of nanopatterned extracellular matrix (ECM) proteins in parallel.

引用

页码：1472 / 1476

页数：5

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