Novel Tools for Prostate Cancer Prognosis, Diagnosis, and Follow-Up

被引：49

作者：

Dimakakos, Andreas ^{[1
]}

Armakolas, Athanasios ^{[1
]}

Koutsilieris, Michael ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Sch Med, Physiol Lab, Athens 11527, Greece

来源：

BIOMED RESEARCH INTERNATIONAL | 2014年 / 2014卷

关键词：

CIRCULATING TUMOR-CELLS; FACTOR-I RECEPTOR; MESENCHYMAL TRANSITION EMT; ANTIGEN MESSENGER-RNA; GROWTH-FACTOR; MEMBRANE ANTIGEN; PLASMINOGEN-ACTIVATOR; IGF1R INHIBITION; IMMUNE-RESPONSE; BONE METASTASIS;

D O I：

10.1155/2014/890697

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Prostate-specific antigen (PSA) is the main diagnostic tool when it comes to prostate cancer but it possesses serious limitations. Therefore, there is an urgent need for more sensitive and specific biomarkers for prostate cancer prognosis and patient follow-up. Recent advances led to the discovery of many novel diagnostic/prognostic techniques and provided us with many worthwhile candidates. This paper briefly reviews the most promising biomarkers with respect to their implementation in screening, early detection, diagnostic confirmation, prognosis, and prediction of therapeutic response or monitoring disease and recurrence; and their use as possible therapeutic targets. This review also examines the possible future directions in the field of prostate cancer marker research.

引用

页数：9

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