The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

被引：29
|
作者：
Goilav, Beatrice [1 ]
Putterman, Chaim [2 ,3 ]
机构：
[1] Albert Einstein Coll Med, Childrens Hosp Montefiore, Div Pediat Nephrol, Bronx, NY 10461 USA
[2] Albert Einstein Coll Med, Div Rheumatol, Bronx, NY 10461 USA
[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
来源：
SEMINARS IN NEPHROLOGY | 2015年 / 35卷 / 05期
基金：
美国国家卫生研究院;
关键词：
Lupus nephritis; nephritogenic antibodies; anti-DNA antibodies; cross-reactivity; GLOMERULAR-BASEMENT-MEMBRANE; MATRIX-METALLOPROTEINASE ACTIVITY; ALPHA-ACTININ ANTIBODIES; DOUBLE-STRANDED DNA; SYSTEMIC-LUPUS; CROSS-REACTIVITY; DSDNA ANTIBODIES; IN-VIVO; NEPHRITOGENIC AUTOANTIBODIES; NUCLEOSOMAL ANTIGENS;
D O I：
10.1016/j.semnephrol.2015.08.005
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged similar to 50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码：439 / 443
页数：5
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