The Role of Anti-DNA Antibodies in the Development of Lupus Nephritis: A Complementary, or Alternative, Viewpoint?

被引：29

作者：

Goilav, Beatrice ^{[1
]}

Putterman, Chaim ^{[2
,3
]}

机构：

[1] Albert Einstein Coll Med, Childrens Hosp Montefiore, Div Pediat Nephrol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Div Rheumatol, Bronx, NY 10461 USA

[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

来源：

SEMINARS IN NEPHROLOGY | 2015年 / 35卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Lupus nephritis; nephritogenic antibodies; anti-DNA antibodies; cross-reactivity; GLOMERULAR-BASEMENT-MEMBRANE; MATRIX-METALLOPROTEINASE ACTIVITY; ALPHA-ACTININ ANTIBODIES; DOUBLE-STRANDED DNA; SYSTEMIC-LUPUS; CROSS-REACTIVITY; DSDNA ANTIBODIES; IN-VIVO; NEPHRITOGENIC AUTOANTIBODIES; NUCLEOSOMAL ANTIGENS;

D O I：

10.1016/j.semnephrol.2015.08.005

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Kidney disease, or lupus nephritis, is the organ involvement that is most closely associated with specific autoantibodies in patients with SLE. The concept of anti-DNA antibodies being instrumental in the pathogenesis of lupus nephritis emerged similar to 50 years ago, and has been a topic of debate ever since. This article focuses on the description of the renal sub-cellular targets of nephritogenic autoantibodies and offers a counter-point opinion to the article by Pedersen et al. In addition, we provide an overview of some of the mechanisms by which anti-DNA antibodies bind to their renal targets and the pathogenic relevance to clinical nephritis. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：439 / 443

页数：5

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