Lymphocyte-derived interleukin-17A adds another brick in the wall of inflammation-induced breast carcinogenesis

被引：32

作者：

Bastid, Jeremy ^{[1
]}

Bonnefoy, Nathalie ^{[2
]}

Eliaou, Jean-Francois ^{[2
,3
,4
]}

Bensussan, Armand ^{[5
,6
]}

机构：

[1] OREGA Biotech, Ecully, France

[2] Univ Montpellier I, INSERM, U896, IRCM,Inst Rech Canc Montpellier,CRLC Val dAurelle, Montpellier, France

[3] Univ Montpellier I, Ctr Hosp Reg Univ Montpellier, Dept Immunol, Montpellier, France

[4] Univ Montpellier I, Fac Med, Montpellier, France

[5] INSERM, UMR S 976, Paris, France

[6] Univ Paris Diderot, Sorbonne Paris Cite, Lab Immunol Dermatol & Oncol, Paris, France

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 03期

关键词：

breast cancer; ERK kinases; IL-17A; tumor infiltrating lymphocytes; chemoresistance; monoclonal antibodies; TUMOR; INVASIVENESS; EXPRESSION;

D O I：

10.4161/onci.28273

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have previously reported that a subset of breast tumors are infiltrated with IL-17A-producing tumor-associated lymphocytes and that IL-17A cytokine is principally associated with estrogen receptor negative (ER-) and triple negative, basal-like tumors. We established that IL-17A producing lymphocytes induced cancer cell proliferation, chemoresistance, and invasion, indicating that IL-17A is a potential therapeutic target for breast malignancies.

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