A facile method for hydroxytrifluoromethylation of alkenes with Langlois reagent and DMSO

被引：57
作者：
Shen, Wei-Guo [1 ,2 ]
Wu, Qing-Yan [1 ,2 ]
Gong, Xing-Yu [1 ,2 ]
Ao, Gui-Zhen [1 ,2 ]
Liu, Feng [1 ,2 ,3 ]
机构：
[1] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Coll Pharmaceut Sci, 199 Ren Ai Rd, Suzhou 215123, Jiangsu, Peoples R China
[2] Soochow Univ, Coll Pharmaceut Sci, Dept Med Chem, 199 Ren Ai Rd, Suzhou 215123, Jiangsu, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China
来源：
GREEN CHEMISTRY | 2019年 / 21卷 / 11期
基金：
中国国家自然科学基金;
关键词：
PHOTOREDOX-CATALYZED TRIFLUOROMETHYLATION; RADICAL TRIFLUOROMETHYLATION; SODIUM TRIFLUOROMETHANESULFINATE; 3-COMPONENT OXYTRIFLUOROMETHYLATION; OXIDATIVE TRIFLUOROMETHYLATION; SANDMEYER TRIFLUOROMETHYLATION; VICINAL DIFUNCTIONALIZATION; TRI-/DIFLUOROMETHYLATION; ORGANOFLUORINE CHEMISTRY; UNACTIVATED ALKENES;
D O I：
10.1039/c9gc00886a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A practical hydroxytrifluoromethylation of alkenes using the Langlois reagent as the trifluoromethyl source and DMSO as the oxidant is described. This reaction is mild and operationally simple, without exclusion of either moisture or oxygen, allowing access to a wide range of beta-trifluoromethyl alcohols in useful yields. This transformation is environmentally friendly and can be easily scaled up to gram level.
引用
收藏
页码：2983 / 2987
页数：5
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