Enantiomer separation of chiral pharmaceuticals by capillary electrochromatography

被引：135

作者：

Wistuba, D ^{[1
]}

Schurig, V ^{[1
]}

机构：

[1] Univ Tubingen, Inst Organ Chem, D-72076 Tubingen, Germany

来源：

JOURNAL OF CHROMATOGRAPHY A | 2000年 / 875卷 / 1-2期

关键词：

reviews; enantiomer separation; electrochromatography; pharmaceutical analysis; molecular imprinting; chiral selectors; saccharides; proteins; peptides; glycoproteins; antibiotics;

D O I：

10.1016/S0021-9673(00)00066-2

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Enantiomer separation of chiral pharmaceuticals by capillary electrochromatography (CEC) is achieved with open-tubular capillaries (o-CEC), with packed capillaries (p-CEC) or with monolithic capillaries. In o-CEC, capillaries are coated with a thin film containing cyclodextrin derivatives, cellulose, proteins, poly-terguride or molecularly imprinted polymers as chiral selectors. In p-CEC, typical chiral HPLC stationary phases such as silica-bonded cyclodextrin or cellulose derivatives, proteins, glycoproteins, macrocyclic antibiotics, quinine-derived and 'Pirkle' selectors, polyacrylamides and molecularly imprinted polymers are used as chiral selectors. Chiral monolithic stationary phases prepared by in situ polymerization into the capillary were also developed for electrochromatographic enantiomer separation. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：255 / 276

页数：22

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