Synthesis, characterization, DNA interactions and antiproliferative activity on glioblastoma of iminopyridine platinum(II) chelate complexes

被引：10

作者：

Posadas, Inmaculada ^{[1
]}

Alonso-Moreno, Carlos ^{[2
]}

Bravo, Ivan ^{[3
]}

Carrillo-Hermosilla, Fernando ^{[4
]}

Garzon, Andres ^{[3
]}

Villaseca, Noemi ^{[3
]}

Lopez-Solera, Isabel ^{[4
]}

Albaladejo, Jose ^{[4
,5
,6
]}

Cena, Valentin ^{[7
]}

机构：

[1] Univ Castilla La Mancha, Unidad Assoc Neurodeath CSIC UCIM, Fac Farm, Dept Ciencias Med, Campus Univ Albacate, Albacate 02071, Spain

[2] Univ Castilla La Mancha, Fac Farm, Dept Quim Inorgan Organ Bioquim, Campus Univ Albacate, Albacate 02071, Spain

[3] Univ Castilla La Mancha, Fac Farm, Dept Quim & Fis, Campus Univ Albacate, Albacate 02071, Spain

[4] Univ Castilla La Mancha, Fac Cienctas Technol Quim, Dept Quim Inorgan Organ Bio, Campus Univ Cludard Real, Cludard Real 13071, Spain

[5] Univ Castilla La Mancha, Fac Ciencias Technol Quim, Dept Quim & Fis, Campus Univ Cludard Real, Cludard Real 13071, Spain

[6] Univ Castilla La Mancha, Unidad Assoc Neurodeath CSIC UCIM, Fac Med, Dept Ciencias med, Campus Univ Albacate, Albacete 02071, Spain

[7] Inst Salud Carlos III, CIBERNED, Madrid, Spain

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2017年 / 168卷

关键词：

Glioblastoma; DNA-binding; Cisplatin derivatives; OF-THE-ART; CROSS-LINKING; PHASE-II; LOG-P; CISPLATIN; CELLS; LIGAND; BINDING; AGENTS; PALLADIUM(II);

D O I：

10.1016/j.jinorgbio.2016.11.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of iminopyridine platinum chelate compounds has been prepared and characterized by NMR spectroscopy and single-crystal X-ray diffraction. The complexes were evaluated in C6 tumoral cells as an in vitro model for glioblastoma multiforme. The DNA-binding properties of these complexes were studied by UV-Vis absorption and fluorescence spectroscopy and Density Functional Theory calculations were performed in an effort to rationalize the observed properties at the molecular level. The most promising drug candidate displayed a similar potency in inducing cell death to the clinically used reference compound and showed significant inhibition of glioblastoma cell proliferation. Moreover, this compound had a safer profile than cisplatin on non-tumoral cells. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：46 / 54

页数：9

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