SBA-15-collagen hybrid material for drug delivery applications

被引：42

作者：

Fagundes, L. B.

Sousa, T. G. F.

Sousa, A.

Silva, V. V.

Sousa, E. M. B.

机构：

[1] CNEN, CDTN, BR-30123970 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Dept Engn Quim, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Dept Quim, Belo Horizonte, MG, Brazil

[4] Univ Val Rio Verde, UninCor, BR-37410000 Tres Coracoes, MG, Brazil

来源：

JOURNAL OF NON-CRYSTALLINE SOLIDS | 2006年 / 352卷 / 32-35期

关键词：

biological systems; biomaterials; sol-gel; aerogel and solution chemistry; organic-inorganic hybrids; sol-gels (xerogels);

D O I：

10.1016/j.jnoncrysol.2006.03.111

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

The development of mesoporous materials offers new possibilities for incorporating biological agents into silica structures and controlling the release kinetics from the matrix due to its well-arranged pore architecture, Indeed, the introduction of appropriate organic compounds into these ceramics has presented excellent results regarding drug release control. In this paper, two types of materials were used to evaluate drug delivery: SBA-15 and a hybrid SBA-15-collagen. The samples were charged with atenolol as a model drug and in vitro release assays were carried out. Significant differences were observed between the release patterns of the different materials, and the release rate was influenced by the presence of collagen in the mesopores. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：3496 / 3501

页数：6

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