Synthesis of 4-alkyl- and 4-(ω-chloroalkyl)-3-hydroxy-5-alkylidenebutenolides based on cyclizations of 4-alkyl- and 4-(ω-chloroalkyl)-1,3-bis(trimethylsilyloxy)buta-1,3-dienes with oxalyl chloride

被引：30

作者：

Nguyen, Van Thi Hong

Bellur, Esen

Appel, Bettina

Langer, Peter

机构：

[1] Univ Rostock, Inst Chem, D-18059 Rostock, Germany

[2] Ernst Moritz Arndt Univ Greifswald, Inst Biochem, D-17487 Greifswald, Germany

[3] Univ Rostock, Leibniz Inst Katalyse, D-18059 Rostock, Germany

来源：

SYNTHESIS-STUTTGART | 2006年 / 17期

关键词：

butenolides; cyclizations; O-heterocycles; silyl enol ethers;

D O I：

10.1055/s-2006-942536

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

4-Alkyl- and 4-(omega-chloroalkyl)-1,3-bis(trimethylsilyloxy)buta-1,3-dienes were prepared from ethyl acetoacetate in three steps. Their cyclization with oxalyl chloride allowed an efficient synthesis of 4-alkyl- and 4-(co-chloroalkyl)-5-alkylidenebutenolides.

引用

收藏

页码：2865 / 2872

页数：8

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