A roadmap to advance dementia research in prevention, diagnosis, intervention, and care by 2025

被引:72
作者
Pickett, James [1 ]
Bird, Cathy [2 ]
Ballard, Clive [3 ]
Banerjee, Sube [4 ]
Brayne, Carol [5 ]
Cowan, Katherine [6 ]
Clare, Linda [7 ]
Comas-Herrera, Adelina [8 ]
Corner, Lynne [9 ,10 ]
Daley, Stephanie [4 ]
Knapp, Martin [8 ]
Lafortune, Louise [5 ]
Livingston, Gill [11 ]
Manthorpe, Jill [12 ]
Marchant, Natalie [11 ]
Moriarty, Jo [12 ]
Robinson, Louise [9 ,10 ]
van Lynden, Clare [13 ]
Windle, Gill [14 ]
Woods, Bob [14 ]
Gray, Katherine [1 ]
Walton, Clare [1 ]
机构
[1] Alzheimers Soc, 43-44 Crutched Friars, London EC3N 2AE, England
[2] Alzheimers Soc, Alzheimers Soc Res Network Volunteer, London, England
[3] Univ Exeter, Sch Med, Exeter, Devon, England
[4] Univ Sussex, Brighton & Sussex Med Sch, Ctr Dementia Studies, Sussex, England
[5] Univ Cambridge, Cambridge Inst Publ Hlth, Sch Clin Med, Cambridge, England
[6] Katherine Cowan Consulting Ltd, E Sussex, England
[7] Univ Exeter, Ctr Res Ageing & Cognit Hlth, Exeter, Devon, England
[8] PSSRU, London Sch Econ & Polit Sci, London, England
[9] Newcastle Univ, Inst Ageing, Newcastle Upon Tyne, Tyne & Wear, England
[10] Newcastle Univ, Inst Hlth & Soc, Newcastle Upon Tyne, Tyne & Wear, England
[11] UCL, Div Psychiat, London, England
[12] Kings Coll London, Social Care Workforce Res Unit, London, England
[13] Alzheimers Res UK, Great Abington, England
[14] Bangor Univ, Dementia Serv Dev Ctr, Bangor, Gwynedd, Wales
关键词
care; dementia research policy; prevention; research funding; risk reduction; social and applied science; 2025 goals for dementia;
D O I
10.1002/gps.4868
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
ObjectiveNational and global dementia plans have focused on the research ambition to develop a cure or disease-modifying therapy by 2025, with the initial focus on investment in drug discovery approaches. We set out to develop complementary research ambitions in the areas of prevention, diagnosis, intervention, and care and strategies for achieving them. MethodsAlzheimer's Society facilitated a taskforce of leading UK clinicians and researchers in dementia, UK funders of dementia research, people with dementia, and carer representatives to develop, using iterative consensus methodology, goals and recommendations to advance dementia research. ResultsThe taskforce developed 5 goals and 30 recommendations. The goals focused on preventing future cases of dementia through risk reduction, maximising the benefit of a dementia diagnosis, improving quality of life, enabling the dementia workforce to improve practice, and optimising the quality and inclusivity of health and social care systems. Recommendations addressed gaps in knowledge and limitations in research methodology or infrastructure that would facilitate research in prioritised areas. A 10-point action plan provides strategies for delivering the proposed research agenda. ConclusionsBy creating complementary goals for research that mirror the need to find effective treatments, we provide a framework that enables a focus for new investment and initiatives. This will support a broader and more holistic approach to research on dementia, addressing prevention, surveillance of population changes in risk and expression of dementia, the diagnostic process, diagnosis itself, interventions, social support, and care for people with dementia and their families.
引用
收藏
页码:900 / 906
页数:7
相关论文
共 13 条
[1]  
[Anonymous], 2017, WELSH GOVT CONSULTAT
[2]  
[Anonymous], 2011, NO IRELAND REGIONAL
[3]  
[Anonymous], 2015, ALZHEIMERS DIS INT W
[4]  
[Anonymous], 2017, SCOTLANDS NATL DEMEN
[5]  
[Anonymous], 2011, EU JOINT PROGRAMME N
[6]  
[Anonymous], 2017, WHO Global action plan on the public health response to dementia 2017-2025
[7]  
[Anonymous], 2016, ALZHEIMERS DEMENT, V12, P334
[8]  
[Anonymous], 2015, 2020 CHALLENGE DEMEN
[9]   Drug development in Alzheimer's disease: the path to 2025 [J].
Cummings, Jeffrey ;
Aisen, Paul S. ;
DuBois, Bruno ;
Froelich, Lutz ;
Jack, Clifford R., Jr. ;
Jones, Roy W. ;
Morris, John C. ;
Raskin, Joel ;
Dowsett, Sherie A. ;
Scheltens, Philip .
ALZHEIMERS RESEARCH & THERAPY, 2016, 8
[10]   Dementia priority setting partnership with the James Lind Alliance: using patient and public involvement and the evidence base to inform the research agenda [J].
Kelly, Sarah ;
Lafortune, Louise ;
Hart, Nicola ;
Cowan, Katherine ;
Fenton, Mark ;
Brayne, Carol .
AGE AND AGEING, 2015, 44 (06) :985-993