Higher vitamin D status and supplementation may be associated with risks

被引:13
作者
Korgavkar, Kaveri [1 ,2 ]
Xiong, Michael [1 ,2 ]
Weinstock, Martin A. [1 ,2 ,3 ,4 ]
机构
[1] Vet Adm Med Ctr, Dermatoepidemiol Unit, Providence, RI 02908 USA
[2] Brown Univ, Alpert Med Sch, Dept Dermatol, Providence, RI 02912 USA
[3] Brown Univ, Alpert Med Sch, Dept Epidemiol, Providence, RI 02912 USA
[4] Rhode Isl Hosp, Dept Dermatol, Providence, RI USA
关键词
epidemiology; vitamin D; SERUM 25-HYDROXYVITAMIN D; RANDOMIZED CONTROLLED-TRIAL; PANCREATIC-CANCER RISK; ISCHEMIC-HEART-DISEASE; MELANOMA SKIN-CANCER; BASAL-CELL CARCINOMA; ALL-CAUSE MORTALITY; PROSTATE-CANCER; MYOCARDIAL-INFARCTION; PROSPECTIVE COHORT;
D O I
10.1684/ejd.2014.2318
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
The prevalence of low vitamin D levels and associated risks has led to an increase in supplementation. However, a ''U-shaped'' relationship has been suggested between vitamin D status and adverse effects, with risks observed both in low and high levels. While risks associated with low levels of vitamin D have been extensively studied, the risks of higher levels of vitamin D have not been as widely circulated. We sought to describe key observed adverse risks with vitamin D supplementation and higher serum 25(OH)-D levels in healthy adult populations.
引用
收藏
页码:428 / 434
页数:7
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