The inhibition of Wnt/β-catenin signaling pathway in human colon cancer cells by sulindac

被引：2

作者：

Tai, Wei-Ping ^{[1
,2
]}

Hu, Pin-Jin ^{[2
]}

Wu, Jing ^{[1
]}

Lin, Xiang-Chun ^{[1
]}

机构：

[1] Capital Med Univ, Beijing Shijitan Hosp, Dept Gastroenterol, Beijing 100038, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510080, Guangdong, Peoples R China

来源：

TUMORI | 2014年 / 100卷 / 01期

关键词：

colorectal cancer; NSAIDs; Wnt/beta-catenin; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; COLORECTAL-CANCER; BETA-CATENIN; EXPRESSION;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aberrant activation of Wnt/beta-catenin signaling plays important roles in the initial development of colon cancer. Sulindac is a commonly used non-steroidal anti-inflammatory drug. We demonstrated the effects of sulindac on growth inhibition, apoptosis induction, and Wnt/beta-catenin signaling suppression in human colon cancer cells. Sulindac significantly inhibited proliferation of HT-29 colon cancer cells in a dose- and time-dependent manner. Sulindac was found to induce the apoptosis of HT-29 cells and inhibit the Wnt/beta-catenin pathway. The inhibition was further confirmed by the decreased protein levels of beta-catenin. The results indicate that sulindac may play a beneficial role in the comprehensive treatment of colon cancer.

引用

页码：97 / 101

页数：5

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