Translational control of interleukin 2 messenger RNA as a molecular mechanism of T cell anergy

被引:32
作者
GarciaSanz, JA
Lenig, D
机构
[1] Basel Institute for Immunology
[2] Basel Institute for Immunology, CH-4005 Basel
关键词
D O I
10.1084/jem.184.1.159
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
T cell stimulation by triggering through the T cell receptor (TCR) in the absence of costimulatory signals or by calcium ionophore induces unresponsiveness in T cells to further stimulation, a phenomenon known as anergy. In freshly isolated T cells, calcium ionophore induces expression of interleukin (IL)-2 messenger (nRNA), but this mRNA is not translated and not loaded with ribosomes. In addition, while plate-bound anti-CD3 stimulation of resting T cells leads to IL-2 mRNA expression and IL-2 secretion, in cells pretreated with calcium ionophore before anti-CD3 stimulation, the IL-2 mRNA remains polysome unloaded and no IL-2 is produced. These observations show that IL-2 expression is controlled at the translational level, by differential ribosome loading. Furthermore, our data suggest that translational control of IL-2 nRNA may be a molecular mechanism by which anergy is attained.
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收藏
页码:159 / 164
页数:6
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