From Monovalent to Multivalent Vaccines, the Exploration for Potential Preventive Strategies Against Hand, Foot, and Mouth Disease (HFMD)

被引:27
作者
He, Xiangchuan [1 ,2 ]
Zhang, Miaomiao [1 ,2 ]
Zhao, Chen [1 ,2 ]
Zheng, Peiyong [3 ]
Zhang, Xiaoyan [1 ,2 ]
Xu, Jianqing [1 ,2 ]
机构
[1] Fudan Univ, Shanghai Med Coll, Shanghai Publ Hlth Clin Ctr, Shanghai 201508, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Inst Biomed Sci, Shanghai 201508, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Longhua Hosp, Shanghai 200032, Peoples R China
基金
中国国家自然科学基金;
关键词
Hand; foot; and mouth disease (HFMD); Inactivated whole virus vaccine; Virus-like particles; Multivalent vaccines; Chimeric vaccines; VIRUS-LIKE PARTICLES; INACTIVATED ENTEROVIRUS 71; COXSACKIEVIRUS A16 INFECTION; PROTECTIVE IMMUNE-RESPONSES; NEUTRALIZING ANTIBODIES; CONFER PROTECTION; LETHAL CHALLENGE; MOUSE MODEL; IN-VIVO; EPITOPE;
D O I
10.1007/s12250-020-00294-3
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Hand, foot, and mouth disease (HFMD) recently emerged as a global public threat. The licensure of inactivated enterovirus A71 (EV-A71) vaccine was the first step in using a vaccine to control HFMD. New challenges arise from changes in the pathogen spectrum while vaccines directed against other common serotypes are in the preclinical stage. The mission of a broad-spectrum prevention strategy clearly favors multivalent vaccines. The development of multivalent vaccines was attempted via the simple combination of potent monovalent vaccines or the construction of chimeric vaccines comprised of epitopes derived from different virus serotypes. The present review summarizes recent advances in HFMD vaccine development and discusses the next steps toward a safe and effective HFMD vaccine that is capable of establishing a cross-protective antibody response.
引用
收藏
页码:167 / 175
页数:9
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