Self-assembling α, γ-cyclic peptides that generate cavities with tunable properties

被引：26

作者：

Rodriguez-Vazquez, Nuria ^{[1
]}

Garcia-Fandino, Rebeca ^{[1
]}

Amorin, Manuel ^{[1
]}

Granja, Juan R. ^{[1
]}

机构：

[1] Univ Santiago de Compostela USC, Dept Organ Chem, Singular Res Ctr Chem Biol & Mol Mat, CIQUS, Santiago De Compostela 15782, Spain

来源：

CHEMICAL SCIENCE | 2016年 / 7卷 / 01期

关键词：

SECONDARY-AMINES; NANOTUBES; COMPLEXES; TRANSPORT; SEGMENTS; CRYSTAL; DESIGN;

D O I：

10.1039/c5sc03187g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The design and synthesis of beta-sheet-based self-assembling cyclic peptides with tunable cavities is described. The incorporation of a gamma-amino acid with a hydroxyl group at C2 allows the incorporation of different groups that modify the internal properties of the resulting dimeric ensemble. These dimers can entrap different guests depending on the properties of the group at C2. The guest defines the geometry of the resulting aggregate.

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页码：183 / 187

页数：5

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