No cross-sectional influence of APOE ε4 dose on clinical tests in Alzheimer's disease

被引：1
|
作者：
Tractenberg, Rochelle E. [1 ,2 ,3 ]
Aisen, Paul S. [1 ]
Hancock, Gregory R. [4 ,5 ]
Rebeck, G. William [6 ]
机构：
[1] Georgetown Univ, Sch Med, Dept Neurol, Washington, DC USA
[2] Georgetown Univ, Sch Med, Dept Biostat, Washington, DC USA
[3] Georgetown Univ, Sch Med, Dept Psychiat, Washington, DC USA
[4] Univ Maryland, Ctr Integrated Latent Variable Res, College Pk, MD 20742 USA
[5] Univ Maryland, Dept Measurement Stat & Evaluat, College Pk, MD 20742 USA
[6] Georgetown Univ, Sch Med, Dept Neurosci, Washington, DC USA
来源：
NEUROBIOLOGY OF AGING | 2009年 / 30卷 / 08期
关键词：
Factor analysis; Statistical; Alzheimer's disease; Genetic risk factor; Cross-sectional analysis;
D O I：
10.1016/j.neurobiolaging.2007.11.006
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
This study sought to determine if there are detectible influences on the symptoms of Alzheimer's disease (AD) from the genetic risk factor for AD, the epsilon 4 allele of apolipoprotein-E (APOE). Using data from two cohorts of AD patients, a cross-sectional latent variable model of AD was tested with three symptom factors explaining variability in the observed variables after taking a general neurological factor into account. No significant influence of epsilon 4 was detected. APOE's effect in AD may occur prior to clinical symptoms, or may simply be more subtle than these instruments can detect. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：1327 / 1328
页数：2
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