A novel β-glucan produced by Paenibacillus polymyxa JB115 induces nitric oxide production in RAW264.7 macrophages

被引：13

作者：

Chang, Zhi-Qiang ^{[1
]}

Lee, Joong-Su ^{[1
]}

Hwang, Mi-Hyun ^{[1
]}

Hong, Joo-Heon ^{[2
]}

Jung, Hee-Kyoung ^{[2
]}

Lee, Sam-Pin ^{[3
]}

Park, Seung-Chun ^{[1
]}

机构：

[1] Kyungpook Natl Univ, Coll Vet Med, Taegu 702701, South Korea

[2] Daegu Technopk, Bio Ind Ctr, Taegu 704701, South Korea

[3] Keimyung Univ, Dept Food Sci & Technol, Taegu 704701, South Korea

来源：

JOURNAL OF VETERINARY SCIENCE | 2009年 / 10卷 / 02期

关键词：

beta-glucan; macrophages; nitric oxide; Paenibacillus polymyxa; PHYSICOCHEMICAL CHARACTERIZATION; PERITONEAL-MACROPHAGES; GROWTH-PERFORMANCE; LIPOPOLYSACCHARIDE; ACTIVATION; RESISTANCE; APOPTOSIS; RESPONSES; PIGS;

D O I：

10.4142/jvs.2009.10.2.165

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The effect of extracellular beta-(1 -> 3), (1 -> 6)-glucan, produced by Paenibacillus polymyxa JB115, on nitric oxide (NO) production in RAW264.7 macrophages was investigated. beta-glucan induced the production of NO by RAW264.7 macrophages in a concentration- and time-dependent manner. Moreover, beta-glucan stimulation increased the mRNA expression of iNOS, COX-2 and IL-6 in RAW264.7 macrophages in a concentration-dependent manner.

引用

页码：165 / 167

页数：3

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