Induction of fetal hemoglobin synthesis by valproate:: Modulation of MAPkinase pathways

被引：41

作者：

Witt, O ^{[1
]}

Mönkemeyer, S ^{[1
]}

Kanbach, K ^{[1
]}

Pekrun, A ^{[1
]}

机构：

[1] Univ Gottingen, Childrens Hosp, Lab Hematol & Canc Res, D-37075 Gottingen, Germany

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2002年 / 71卷 / 01期

关键词：

valproate; valproic acid; fetal hemoglobin; erythroid; MAPK; ERK;

D O I：

10.1002/ajh.10161

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Valproate has been found to stimulate fetal hemoglobin (HbF) synthesis in patients with sickle cell disease. In accordance with these clinical observations, we found a moderate induction of HbF synthesis in K562 erythroid cells in vitro. Investigation of the role of the mitogen-activated protein kinase (MAPK) pathways by Western blot analysis and use of specific kinase inhibitors suggests that inhibition of ERK pathway and activation of the p38 pathway may contribute to the HbF-inducing activity of valproate. (C) 2002 Wiley-Liss, Inc.

引用

页码：45 / 46

页数：2

共 8 条

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