Clinical Evaluation of Multiple Inflammation Biomarkers for Diagnosis and Prognosis for Patients with Systemic Inflammatory Response Syndrome

被引：33
作者：
Reichsoellner, M. [1 ]
Raggam, R. B. [2 ,3 ]
Wagner, J. [1 ]
Krause, R. [1 ]
Hoenigl, M. [1 ,4 ,5 ]
机构：
[1] Med Univ Graz, Dept Internal Med, Sect Infect Dis & Trop Med, Graz, Austria
[2] Med Univ Graz, Inst Clin Med, Graz, Austria
[3] Med Univ Graz, Chem Lab Diagnost, Graz, Austria
[4] Med Univ Graz, Dept Internal Med, Div Pulmonol, Graz, Austria
[5] Univ Calif San Diego, Dept Med, Div Infect Dis, San Diego, CA 92103 USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2014年 / 52卷 / 11期
关键词：
SEPSIS; PROCALCITONIN; BACTEREMIA; INTERLEUKIN-6; RECEPTOR;
D O I：
10.1128/JCM.01954-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A multiplexed biomarker bundle consisting of nine different inflammation markers was evaluated regarding their diagnostic and prognostic performances in 159 adult systemic inflammatory response syndrome (SIRS) patients enrolled at the emergency department. Fibronectin, interleukin-8 (IL-8), biotin, and neutrophil gelatinase-associated lipocalin (NGAL) were the most robust markers but were not superior to the already established markers IL-6, C-reactive protein (CRP), procalcitonin (PCT), and soluble urokinase plasminogen activator receptor (suPAR).
引用
收藏
页码：4063 / 4066
页数：4
相关论文
共 14 条
[1]   DEFINITIONS FOR SEPSIS AND ORGAN FAILURE AND GUIDELINES FOR THE USE OF INNOVATIVE THERAPIES IN SEPSIS [J].
BONE, RC ;
BALK, RA ;
CERRA, FB ;
DELLINGER, RP ;
FEIN, AM ;
KNAUS, WA ;
SCHEIN, RMH ;
SIBBALD, WJ .
CHEST, 1992, 101 (06) :1644-1655
[2]   Toward resolving the challenges of sepsis diagnosis [J].
Carrigan, SD ;
Scott, G ;
Tabrizian, M .
CLINICAL CHEMISTRY, 2004, 50 (08) :1301-1314
[3]   Low serum procalcitonin level accurately predicts the absence of bacteremia in adult patients with acute fever [J].
Chirouze, C ;
Schuhmacher, H ;
Rabaud, C ;
Gil, H ;
Khayat, N ;
Estavoyer, JM ;
May, T ;
Hoen, B .
CLINICAL INFECTIOUS DISEASES, 2002, 35 (02) :156-161
[4]   Diagnostic value of procalcitonin, interleukin-6, and interleukin-8 in critically ill patients admitted with suspected sepsis [J].
Harbarth, S ;
Holeckova, K ;
Froidevaux, C ;
Pittet, D ;
Ricou, B ;
Grau, GE ;
Vadas, L ;
Pugin, J .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (03) :396-402
[5]   Procalcitonin fails to predict bacteremia in SIRS patients: a cohort study [J].
Hoenigl, M. ;
Raggam, R. B. ;
Wagner, J. ;
Prueller, F. ;
Grisold, A. J. ;
Leitner, E. ;
Seeber, K. ;
Prattes, J. ;
Valentin, T. ;
Zollner-Schwetz, I. ;
Schilcher, G. ;
Krause, R. .
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2014, 68 (10) :1278-1281
[6]   Diagnostic accuracy of soluble urokinase plasminogen activator receptor (suPAR) for prediction of bacteremia in patients with systemic inflammatory response syndrome [J].
Hoenigl, Martin ;
Raggam, Reinhard B. ;
Wagner, Jasmin ;
Valentin, Thomas ;
Leitner, Eva ;
Seeber, Katharina ;
Zollner-Schwetz, Ines ;
Krammer, Werner ;
Prueller, Florian ;
Grisold, Andrea J. ;
Krause, Robert .
CLINICAL BIOCHEMISTRY, 2013, 46 (03) :225-229
[7]   Use of plasma C-reactive protein, procalcitonin, neutrophils, macrophage migration inhibitory factor, soluble urokinase-type plasminogen activator receptor, and soluble triggering receptor expressed on myeloid cells-1 in combination to diagnose infections: a prospective study [J].
Kofoed, Kristian ;
Andersen, Ove ;
Kronborg, Gitte ;
Tvede, Michael ;
Petersen, Janne ;
Eugen-Olsen, Jesper ;
Larsen, Klaus .
CRITICAL CARE, 2007, 11 (02)
[8]  
Mamani Mojgan, 2012, Acta Med Iran, V50, P404
[9]   Association of plasma neutrophil gelatinase-associated lipocalin (NGAL) with sepsis and acute kidney dysfunction [J].
Martensson, Johan ;
Bell, Max ;
Xu, Shengyuan ;
Bottai, Matteo ;
Ravn, Bo ;
Venge, Per ;
Martling, Claes-Roland .
BIOMARKERS, 2013, 18 (04) :349-356
[10]   Plasma fibronectin as a marker of sepsis [J].
Martín, GR ;
Prieto, JP ;
de Cabo, JV ;
Lus, LG ;
Barberán, J ;
Landa, JMG ;
Fernández, C .
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2004, 8 (04) :236-243
12